Ítem
Solo Metadatos

Signaling pathways mTOR and AKT in epilepsy

Mostrar el registro sencillo de la publicación
dc.creatorRomero-Leguizamón C.R.spa
dc.creatorRamírez-Latorre J.A.spa
dc.creatorMora-Muñoz L.spa
dc.creatorGuerrero-Naranjo A.spa
dc.date.accessioned2020-05-25T23:59:55Z
dc.date.available2020-05-25T23:59:55Z
dc.date.created2016spa
dc.description.abstractIntroduction. The signaling pathway AKT/mTOR is a central axis in regulating cellular processes, particularly in neurological diseases. In the case of epilepsy, it has been observed alteration in the pathophysiological process of the same. However, they have not described all the mechanisms of these signaling pathways that could open the opportunity to new research and therapeutic strategies. Aim. To review existing partnerships between intracellular signaling pathways AKT and mTOR in the pathophysiology of epilepsy. Development. Epilepsy is a disease with a high epidemiological impact globally, so it is widely investigated regarding the pathophysiological components thereof. In that search they have been involved different intracellular signaling pathways in neurons, as determinants epileptogenic. Advances in this field have even allowed the successful implementation of new therapeutic strategies and to open the way to new research in the field. Conclusions. Improving knowledge about the pathophysiological role of the signaling pathway mTOR/AKT in epilepsy can raise new investigations regarding therapeutic alternatives. The use of mTOR inhibitors, has emerged in recent years as effective in treating this disease entity alternative however is clear the necessity of continue the research for new drug therapies. © 2016 Revista de Neurología.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn2100010
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23132
dc.language.isoengspa
dc.publisherRevista de Neurologiaspa
dc.relation.citationEndPage41
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage33
dc.relation.citationTitleRevista de Neurologia
dc.relation.citationVolumeVol. 63
dc.relation.ispartofRevista de Neurologia, ISSN:2100010, Vol.63, No.1 (2016); pp. 33-41spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978394323&partnerID=40&md5=034975484c1bbfceb05c3aba6192f8fbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMammalian target of rapamycinspa
dc.subject.keywordMammalian target of rapamycin inhibitorspa
dc.subject.keywordProtein kinase bspa
dc.subject.keywordProtein kinase bspa
dc.subject.keywordTarget of rapamycin kinasespa
dc.subject.keywordCell cycle regulationspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHumanspa
dc.subject.keywordIntracellular signalingspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordReviewspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordMetabolismspa
dc.subject.keywordNerve cellspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHumansspa
dc.subject.keywordNeuronsspa
dc.subject.keywordProto-oncogene proteins c-aktspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordTor serine-threonine kinasesspa
dc.subject.keywordAktspa
dc.subject.keywordCellular signaling pathwaysspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordMtorspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordTreatmentspa
dc.subject.keywordTuberous sclerosisspa
dc.titleSignaling pathways mTOR and AKT in epilepsyspa
dc.title.TranslatedTitleVías de señalización mTOR y AKT en epilepsiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos