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Screening for mutations of the FOXO4 gene in premature ovarian failure patients

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dc.creatorFonseca Mendoza, Dora Janeth
dc.creatorGarzón, Elianaspa
dc.creatorLakhal, Besmaspa
dc.creatorBraham, Rimspa
dc.creatorOjeda, Diegospa
dc.creatorElghezal, Hatemspa
dc.creatorSaâd, Alispa
dc.creatorRestrepo Fernández, Carlos Martín
dc.creatorLaissue, Paul
dc.date.accessioned2020-05-25T23:58:45Z
dc.date.available2020-05-25T23:58:45Z
dc.date.created2012spa
dc.description.abstractFOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.rbmo.2011.11.017
dc.identifier.issn14726483
dc.identifier.issn14726491
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22923
dc.language.isoengspa
dc.relation.citationEndPage341
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage339
dc.relation.citationTitleReproductive BioMedicine Online
dc.relation.citationVolumeVol. 24
dc.relation.ispartofReproductive BioMedicine Online, ISSN:14726483, 14726491, Vol.24, No.3 (2012); pp. 339-341spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84858001519&doi=10.1016%2fj.rbmo.2011.11.017&partnerID=40&md5=d7e01bcc8a230dfbfba700b7d501e086spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordFoxo4 proteinspa
dc.subject.keyworddnaeng
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDna flanking regionspa
dc.subject.keywordExonspa
dc.subject.keywordFemalespa
dc.subject.keywordFemale infertilityspa
dc.subject.keywordGene expressionspa
dc.subject.keywordGene mutationspa
dc.subject.keywordGenetic screeningspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordOpen reading framespa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPremature ovarian failurespa
dc.subject.keywordPromoter regionspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordTunisiaspa
dc.subject.keywordAdultspa
dc.subject.keywordDna mutational analysisspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordHumansspa
dc.subject.keywordMutationspa
dc.subject.keywordOpen reading framesspa
dc.subject.keywordPrimary ovarian insufficiencyspa
dc.subject.keywordPromoter regionseng
dc.subject.keywordSequence analysiseng
dc.subject.keywordTranscription factorsspa
dc.subject.keywordTunisiaspa
dc.subject.keywordFemale infertilityspa
dc.subject.keywordFoxo4spa
dc.subject.keywordPremature ovarian failurespa
dc.titleScreening for mutations of the FOXO4 gene in premature ovarian failure patientsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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