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Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy

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dc.creatorFranco-Chuaire M.L.spa
dc.creatorSánchez-Corredor M.C.spa
dc.creatorChuaire-Noack L.spa
dc.date.accessioned2020-05-25T23:55:42Z
dc.date.available2020-05-25T23:55:42Z
dc.date.created2013spa
dc.description.abstractThe epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein.eng
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22184
dc.language.isoengspa
dc.relation.citationEndPage205
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage186
dc.relation.citationTitleInvestigacion Clinica (Venezuela)
dc.relation.citationVolumeVol. 54
dc.relation.ispartofInvestigacion Clinica (Venezuela), Vol.54, No.2 (2013); pp. 186-205spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84878919672&partnerID=40&md5=81ae0438e450a786e159603077c8e347spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBeta cateninspa
dc.subject.keywordFibroblast growth factorspa
dc.subject.keywordMatrilysinspa
dc.subject.keywordMicrorna 200spa
dc.subject.keywordNerve cell adhesion moleculespa
dc.subject.keywordOsteogenic protein 1spa
dc.subject.keywordProtein p120spa
dc.subject.keywordTranscription factor pax2spa
dc.subject.keywordTranscription factor snailspa
dc.subject.keywordTransforming growth factor betaspa
dc.subject.keywordUvomorulinspa
dc.subject.keywordWt1 proteinspa
dc.subject.keywordApoptosisspa
dc.subject.keywordArticlespa
dc.subject.keywordCancer therapyspa
dc.subject.keywordCarcinogenesisspa
dc.subject.keywordCell adhesionspa
dc.subject.keywordCell polarityspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordEmbryo developmentspa
dc.subject.keywordEpithelial mesenchymal transitionspa
dc.subject.keywordFibrosisspa
dc.subject.keywordHumanspa
dc.subject.keywordMetastasisspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordStem cellspa
dc.subject.keywordTumor growthspa
dc.subject.keywordTumor microenvironmentspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntineoplastic agentsspa
dc.subject.keywordCell adhesionspa
dc.subject.keywordCell adhesion moleculesspa
dc.subject.keywordCell differentiationspa
dc.subject.keywordCell movementspa
dc.subject.keywordCell polarityspa
dc.subject.keywordCell transformationeng
dc.subject.keywordDisease progressionspa
dc.subject.keywordEmbryonic developmentspa
dc.subject.keywordEpithelial-mesenchymal transitionspa
dc.subject.keywordFibrosisspa
dc.subject.keywordHumansspa
dc.subject.keywordIntracellular signaling peptides and proteinsspa
dc.subject.keywordMicrornasspa
dc.subject.keywordMolecular targeted therapyspa
dc.subject.keywordNeoplasm proteinsspa
dc.subject.keywordNeoplasmsspa
dc.subject.keywordNeoplastic stem cellsspa
dc.subject.keywordRnaeng
dc.subject.keywordSignal transductionspa
dc.subject.keywordCadherinsspa
dc.subject.keywordCancerspa
dc.subject.keywordCancer stem cellsspa
dc.subject.keywordCell polarityspa
dc.subject.keywordDifferentiationspa
dc.subject.keywordMicrornaspa
dc.titleEpithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapyspa
dc.title.TranslatedTitleTransición epitelio-mesenquimática (TEM): Principios e impacto clínico en la terapia contra el cáncerspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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