Ítem
Solo Metadatos

Autoimmune disease aggregation in families with primary Sjögren's syndrome

Mostrar el registro sencillo de la publicación
dc.creatorAnaya, Juan-Manuelspa
dc.creatorTobon G.J.spa
dc.creatorVega P.spa
dc.creatorCastiblanco J.spa
dc.date.accessioned2020-05-25T23:56:31Z
dc.date.available2020-05-25T23:56:31Z
dc.date.created2006spa
dc.description.abstractObjective. Diverse autoimmune diseases may coexist in the same individual and in families, implying a common etiology. We examined the aggregation of autoimmune diseases among first-degree relatives (FDR) of patients with primary Sjögren's syndrome (pSS). Methods. This was a population-based case-control family study in which 101 families of women classified as having pSS according to the revised American-European criteria and 124 families of matched controls without autoimmune disease were enrolled to investigate the presence of autoimmune diseases. We performed a genetic analysis that included familial correlation and recurrent risk ratios. Results. In family cases, 38% had at least one FDR with an autoimmune disease, versus 22% in control families [odds ratio (OR) 2.2, 95%) confidence interval (CI) 1.2-3.9, p = 0.01]. An autoimmune disease was registered for 7.3% of 876 patients' FDR as compared with 3.85% of 857 controls' FDR (OR 1.97, 95% CI 1.28-3.03, p = 0.002). The most frequent autoimmune diseases registered among the pSS patients' FDR were autoimmune thyroid disease (AITD), systemic lupus erythematosus, and rheumatoid arthritis, which disclosed aggregation. The proband phenotype (i.e., pSS) was correlated with AITD, systemic sclerosis, and all autoimmune diseases when considered together as a trait. Maternal transmission of the autoimmunity trait was observed in cases but not in controls. Conclusion. Our results indicate that autoimmune diseases cluster within families of patients with pSS. This familial aggregation of autoimmune diseases adds further evidence that clinically different autoimmune phenotypes might share common susceptibility gene variants, which acting in epistatic pleitropy may represent risk factors for autoimmunity.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn14992752
dc.identifier.issn0315162X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22449
dc.language.isoengspa
dc.relation.citationEndPage2234
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage2227
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 33
dc.relation.ispartofJournal of Rheumatology, ISSN:14992752, 0315162X, Vol.33, No.11 (2006); pp. 2227-2234spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33750987918&partnerID=40&md5=fbc1b2b35a9bed07828968631efe4684spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hyperparathyroidismspa
dc.subject.keywordAutoimmune hypoparathyroidismspa
dc.subject.keywordAutoimmune thyroid diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEpistasisspa
dc.subject.keywordFamilial diseasespa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenetic traitspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordParentspa
dc.subject.keywordPhenotypespa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRecurrence riskspa
dc.subject.keywordRelativespa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordVitiligospa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPedigreespa
dc.subject.keywordPhenotypespa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmune thyroid diseasespa
dc.subject.keywordGeneticsspa
dc.subject.keywordInheritance patternsspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjögren's syndromespa
dc.titleAutoimmune disease aggregation in families with primary Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos