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Genetic Influence of PTPN22 R620W Polymorphism in Tuberculosis

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dc.creatorGomez L.M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorMartin J.spa
dc.date.accessioned2020-05-26T00:10:12Z
dc.date.available2020-05-26T00:10:12Z
dc.date.created2005spa
dc.description.abstractThe PTPN22 gene codes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative regulatory effect on T-cell activation. Because Lyp is an important molecule involved in the inflammatory response, and its levels are increased in cells that participate in the immune response against Mycobacterium tuberculosis, we hypothesized that the functional PTPN22 C1858T polymorphism could be a genetic factor predisposing to the development of tuberculosis (TB). Accordingly, we undertook an association study in which 113 patients with pulmonary TB and 161 matched healthy controls stratified by the tuberculin skin test (TST) were examined. Significant skewing was observed when T allele frequencies of patients with TB and all controls were compared (P = 0.04, odds ratio = 0.3; 95% confidence interval = 0.08-1.04) and frequencies of patients with TB and TST+ healthy controls were compared (P = 0.01, odds ratio = 0.2; 95% confidence interval = 0.05-0.79). No stratification was detected between patients and control samples. These results suggest that the T allele may be a factor protecting against development of TB once the immune system recognizes M. tuberculosis (i.e., TST+ individuals), whereas the C allele may be a risk factor for development of overt TB. The results also indicate that an association opposite that between the PTPN22 polymorphism and TB exists between TB and autoimmunity. © 2006 American Society for Histocompatibility and Immunogenetics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2005.11.008
dc.identifier.issn1988859
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24216
dc.language.isoengspa
dc.relation.citationEndPage1247
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage1242
dc.relation.citationTitleHuman Immunology
dc.relation.citationVolumeVol. 66
dc.relation.ispartofHuman Immunology, ISSN:1988859, Vol.66, No.12 (2005); pp. 1242-1247spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33745652977&doi=10.1016%2fj.humimm.2005.11.008&partnerID=40&md5=3c89dd128d88c2ecea190ee90b22a109spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordProteinspa
dc.subject.keywordProtein tyrosine phosphatase nonreceptor 22 proteinspa
dc.subject.keywordpulmonaryeng
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordUnclassified drugspa
dc.subject.keywordProtein tyrosine phosphatasespa
dc.subject.keywordProtein tyrosine phosphatase lypspa
dc.subject.keywordProtein-tyrosine phosphatase lypspa
dc.subject.keywordAdultspa
dc.subject.keywordAntigen recognitionspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordGenetic codespa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHeredityspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune systemspa
dc.subject.keywordLung tuberculosisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRandomizationspa
dc.subject.keywordRisk factorspa
dc.subject.keywordTuberculin testspa
dc.subject.keywordCase control studyspa
dc.subject.keywordColombiaspa
dc.subject.keywordGeneticsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordLung tuberculosisspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordAdultspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtein-tyrosine-phosphatasespa
dc.subject.keywordTuberculosiseng
dc.subject.keywordAutoimmunityspa
dc.subject.keywordDelayed-type hypersensitivityspa
dc.subject.keywordPtpn22spa
dc.subject.keywordTuberculin skin testspa
dc.subject.keywordTuberculosisspa
dc.titleGenetic Influence of PTPN22 R620W Polymorphism in Tuberculosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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