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What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?

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dc.creatorLópez, Carolinaspa
dc.creatorYepes-Pérez, Yoelisspa
dc.creatorHincapié-Escobar, Nataliaspa
dc.creatorDíaz Arévalo, Diana
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:08:31Z
dc.date.available2020-05-26T00:08:31Z
dc.date.created2017spa
dc.description.abstractMalaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by P. vivax. © 2017 López, Yepes-Pérez, Hincapié-Escobar, Díaz-Arévalo and Patarroyo.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.00126
dc.identifier.issn16643224
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24090
dc.language.isoengspa
dc.publisherFrontiers Research Foundationspa
dc.relation.citationIssueNo. FEB
dc.relation.citationTitleFrontiers in Immunology
dc.relation.citationVolumeVol. 8
dc.relation.ispartofFrontiers in Immunology, ISSN:16643224, Vol.8, No.FEB (2017)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85014341523&doi=10.3389%2ffimmu.2017.00126&partnerID=40&md5=061b587217ac2997fa0bdaf68d6b7f89spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApical membrane antigen 1spa
dc.subject.keywordChemokinespa
dc.subject.keywordCircumsporozoite proteinspa
dc.subject.keywordDuffy binding proteinspa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMerozoite surface protein 3spa
dc.subject.keywordMerozoite surface protein 9spa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordRecombinant proteinspa
dc.subject.keywordSynthetic peptidespa
dc.subject.keywordTranscription factorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdaptive immunityspa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordB lymphocytespa
dc.subject.keywordCell invasionspa
dc.subject.keywordDisease severityspa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHelper cellspa
dc.subject.keywordHost cellspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordInflammationspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMacrophage activationspa
dc.subject.keywordMinor histocompatibility complexspa
dc.subject.keywordNatural killer cellspa
dc.subject.keywordNeuromuscular blockingspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPhagolysosomespa
dc.subject.keywordPlasmodium vivax malariaspa
dc.subject.keywordReviewspa
dc.subject.keywordSerologyspa
dc.subject.keywordSporozoitespa
dc.subject.keywordT lymphocyte activationspa
dc.subject.keywordVaccine immunogenicityspa
dc.subject.keywordAntigenicityspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivaxspa
dc.titleWhat is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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