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Exercise and postprandial lipemia : Effects on vascular health in inactive adults

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dc.contributor.gruplacCentro de Estudios en Medición de la Actividad Física (CEMA)spa
dc.creatorRamírez-Vélez, Robinson
dc.creatorCorrea-Rodríguez, María
dc.creatorTordecilla Sanders, María Alejandra
dc.creatorAya-Aldana, Viviana
dc.creatorIzquierdo, Mikel
dc.creatorCorrea Bautista, Jorge Enrique
dc.creatorÁlvarez, Cristian
dc.creatorGarcia-Hermoso, Antonio
dc.creator.googleRamírez-Vélez, Robinson
dc.creator.googleCorrea-Rodríguez, María
dc.creator.googleTordecilla-Sanders, Alejandra
dc.creator.googleAya-Aldana, Viviana
dc.creator.googleIzquierdo, Mikel
dc.creator.googleCorrea-Bautista, Jorge Enrique
dc.creator.googleÁlvarez, Cristian
dc.creator.googleGarcia-Hermoso, Antonio
dc.date.accessioned2019-09-30T13:40:35Z
dc.date.available2019-09-30T13:40:35Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractBackground: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016. © 2018 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1186/s12944-018-0719-3
dc.identifier.issn1476-511X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20361
dc.language.isoengspa
dc.relation.citationTitleLipids in Health and Disease
dc.relation.citationVolumeVol. 17
dc.relation.ispartofLipids in Health and Disease, ISSN:1476-511X, Vol. 17 (2018)spa
dc.relation.urihttps://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0719-3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationEndemann, D.H., Schiffrin, E.L., Endothelial dysfunction (2004) J Am Soc Nephrol, 15 (8), pp. 1983-1992. , 1:CAS:528:DC%2BD2cXlvVKmurY%3D 15284284spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectGlucosespa
dc.subjectHigh-Fatspa
dc.subjectTriacylglycerolspa
dc.subjectCholesterolspa
dc.subjectArterial Stiffnessspa
dc.subjectAugmentation Indexspa
dc.subjectCholesterol Blood Levelspa
dc.subjectComparative Effectivenessspa
dc.subjectControlled Studyspa
dc.subjectDiet Restrictionspa
dc.subjectEndothelial Dysfunctionspa
dc.subjectExercisespa
dc.subjectGlucose Blood Levelspa
dc.subjectHigh Intensity Trainingspa
dc.subjectHumanspa
dc.subjectHuman Experimentspa
dc.subjectHyperlipidemiaspa
dc.subjectLipid Dietspa
dc.subjectMalespa
dc.subjectModerate Continuous Trainingspa
dc.subjectNormal Humanspa
dc.subjectPhysical Inactivityspa
dc.subjectPostprandial Statespa
dc.subjectProspective Studyspa
dc.subjectPulse Wavespa
dc.subjectRandomized Controlled Trialspa
dc.subjectBloodspa
dc.subjectExercisespa
dc.subjectHyperlipidemiaspa
dc.subjectPathophysiologyspa
dc.subjectPhysiologyspa
dc.subjectPostprandial Statespa
dc.subjectVascular Endotheliumspa
dc.subjectVasodilatationspa
dc.subjectCholesterolspa
dc.subjectDietspa
dc.subjectEndotheliumspa
dc.subjectExercisespa
dc.subjectHyperlipidemiasspa
dc.subjectMalespa
dc.subjectPostprandial Periodspa
dc.subjectVascular Stiffnessspa
dc.subjectVasodilationspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordPostprandial lipemiaspa
dc.subject.keywordEndothelial functionspa
dc.subject.keywordExercise intensityspa
dc.subject.keywordHigh-intensity exercisespa
dc.subject.keywordModerate continuous trainingspa
dc.subject.keywordArticlespa
dc.subject.keywordFemalespa
dc.subject.keywordAdultspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.lembGlucosaspa
dc.subject.lembAzucar en el organismospa
dc.subject.lembColesterolspa
dc.titleExercise and postprandial lipemia : Effects on vascular health in inactive adultsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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