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Is narcolepsy a classical autoimmune disease?

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dc.creatorArango, María-Teresaspa
dc.creatorKivity, Shayespa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:58:05Z
dc.date.available2020-05-25T23:58:05Z
dc.date.created2015spa
dc.description.abstractNarcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the disease with the HLA DQB1?06:02, as well as the link with environmental factors and are important clues supporting this theory. Recently, the association between the occurrence of the disease and vaccination campaign after the 2009 H1N1 pandemic highlighted the importance to increase the knowledge in the Pandora box of the vaccines. This review discusses the last finding regarding the pathogenesis of the disease and its relationship with the H1N1 vaccines. © 2014 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.phrs.2014.10.005
dc.identifier.issn10436618
dc.identifier.issn10961186
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22798
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage12
dc.relation.citationStartPage6
dc.relation.citationTitlePharmacological Research
dc.relation.citationVolumeVol. 92
dc.relation.ispartofPharmacological Research, ISSN:10436618, 10961186, Vol.92,(2015); pp. 6-12spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84923268310&doi=10.1016%2fj.phrs.2014.10.005&partnerID=40&md5=236dd67032aa9ecd668f350a06a97960spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlpha tocopherolspa
dc.subject.keywordAs03 vaccinespa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordCathepsin gspa
dc.subject.keywordDna methyltransferase 1spa
dc.subject.keywordHla dqa1 antigenspa
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordInfluenza vaccinespa
dc.subject.keywordInterleukin 4spa
dc.subject.keywordTrib2 antibodyspa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordVirus vaccinespa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordInfluenza vaccinespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCd4+ t lymphocytespa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordHigh risk patientspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordInfluenzaspa
dc.subject.keywordNarcolepsyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordStreptococcus infectionspa
dc.subject.keywordT lymphocytespa
dc.subject.keywordTh1 cellspa
dc.subject.keywordTh2 cellspa
dc.subject.keywordVaccinationspa
dc.subject.keywordAnimalspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordGeneticsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordInfluenza a virus (h1n1)spa
dc.subject.keywordNarcolepsyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordHumansspa
dc.subject.keywordInfluenza a viruseng
dc.subject.keywordInfluenza vaccinesspa
dc.subject.keywordInfluenzaeng
dc.subject.keywordNarcolepsyspa
dc.subject.keywordAdjuvantspa
dc.subject.keywordAsia syndromespa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordH1n1spa
dc.subject.keywordInfectionsspa
dc.subject.keywordNarcolepsyspa
dc.titleIs narcolepsy a classical autoimmune disease?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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