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Venous-arterial CO2 difference in children with sepsis and its correlation with myocardial dysfunction

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dc.creatorFernández-Sarmiento, Jaimespa
dc.creatorCarcillo, Joseph Aspa
dc.creatorDíaz Del Castillo, Ana Maria Erasospa
dc.creatorBarrera, Pedrospa
dc.creatorOrozco, Rafaelspa
dc.creatorRodríguez, María Angélicaspa
dc.creatorGualdrón, Nathaliespa
dc.date.accessioned2020-05-25T23:58:41Z
dc.date.available2020-05-25T23:58:41Z
dc.date.created2019spa
dc.description.abstractObjective: This study aimed to determine the association between venous-arterial CO2 difference (Pv-aCO2) and clinical outcomes of interest in children with severe sepsis and septic shock. Design: An analytical observational study of a prospective cohort was conducted. Setting: The study was carried out from January 2015 to January 2018 in the pediatric intensive care unit of a referral hospital. Materials and methods: Of a total of 1159 patients who were admitted to pediatric critical care, 375 had severe sepsis and septic shock, of which 67 fulfilled the inclusion criteria. Arterial and venous gases were drawn simultaneously with a transthoracic echocardiogram, Pv-aCO2, and other measures of tissue perfusion such as arterial lactate, venous, and evolution to multiple organ failure. Measurements and main results: Half (53.7%) of the patients were under 24 months old, with a slight predominance of male patients. The main site of infection was the lungs in 56% of the cases, with a 91.2% survival rate. Patients who died had a higher venous lactate level (interquartile range 16.2-33.6, p = 0.02). However, there was no correlation between myocardial dysfunction seen on echocardiogram and a Pv-aCO2 greater than 6 mm Hg in children with severe sepsis and septic shock (r = 0.13). Pv-aCO2 and central venous saturation had low sensitivity to detect multiple organ failure and poor correlation with the number of compromised systems (r = 0.8). Conclusion: Pv-aCO2 was not associated with myocardial dysfunction, measured by echocardiogram, in children with severe sepsis and septic shock. It also did not correlate with the number of organs involved or mortality. © 2019 Fernández-Sarmiento, Carcillo, Eraso-Díaz del Castillo, Barrera, Orozco, Rodríguez, Gualdrón, licensee HBKU Press.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.5339/qmj.2019.18
dc.identifier.issn2538253
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22912
dc.language.isoengspa
dc.publisherHamad Medical Corporationspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleQatar Medical Journal
dc.relation.citationVolumeVol. 2019
dc.relation.ispartofQatar Medical Journal, ISSN:2538253, Vol.2019, No.3 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078417582&doi=10.5339%2fqmj.2019.18&partnerID=40&md5=295590bc18b42b55b245fc98cc051562spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCarbon dioxidespa
dc.subject.keywordLactic acidspa
dc.subject.keywordSteroidspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdrenal insufficiencyspa
dc.subject.keywordAnalytical researchspa
dc.subject.keywordArterial carbon dioxide tensionspa
dc.subject.keywordArticlespa
dc.subject.keywordChildspa
dc.subject.keywordClinical outcomespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordContinuous infusionspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordLactate blood levelspa
dc.subject.keywordLung infectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMultiple organ failurespa
dc.subject.keywordMyocardial diseasespa
dc.subject.keywordObservational studyspa
dc.subject.keywordProspective studyspa
dc.subject.keywordSeptic shockspa
dc.subject.keywordSteroid therapyspa
dc.subject.keywordSurvival ratespa
dc.subject.keywordTissue perfusionspa
dc.subject.keywordTransthoracic echocardiographyspa
dc.subject.keywordVenous oxygen tensionspa
dc.subject.keywordChildrenspa
dc.subject.keywordMortalityspa
dc.subject.keywordMyocardial dysfunctionspa
dc.subject.keywordPv-aco2spa
dc.subject.keywordSepsisspa
dc.subject.keywordSeptic shockspa
dc.subject.keywordVenous saturationspa
dc.titleVenous-arterial CO2 difference in children with sepsis and its correlation with myocardial dysfunctionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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