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Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.

dc.creatorBroseta, J.spa
dc.creatorMorales, F.spa
dc.creatorGarcia, G.spa
dc.creatorSanchez Ledesma, M. J.spa
dc.creatorAnaja, J.spa
dc.creatorGonzalez Darder, J.spa
dc.creatorBarberá, J.spa
dc.date.accessioned2020-08-19T14:41:13Z
dc.date.available2020-08-19T14:41:13Z
dc.date.created1989spa
dc.description.abstractOn the basis of previous experimental and clinical studies1,2 patients with severe spasticity due to spinal cord damage from multiple sclerosis in 8 cases and postraumatic paraplegia in 6 and resistent to all conservative treatments were selected for a trial with morphine and baclofen administered intrathecally through a catheter placed in the spinal subarachnoid space rostral to the affected segments and attached to a subcutaneous reservoir. Whereas morphine single injection did not show any benefit, baclofen bolus injection 30 to 60 ?g, revealed a marked decrease of spasticity and associated symptoms in 8 cases. After checking the clinical effect during 3 weeks and changes in electroneurophysiological studies and bladder manometry the catheter was attached to a subcutaneous programmable pump able to be refilled percutaneously and administered baclofen continuously or more often following a multistep complex programme in total doses of 90 to 150 ?g per day. After a mean follow-up of 5 months all cases showed an absence of spasms and pain, a notable improvement for bettering of sphincter functions and a marked muscle relaxation that improves motor capacity, leading to increased ambulation or mobility. Neither complications nor side-effects were observed.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-3-7091-9029-6_9
dc.identifier.issnISSN: 0065-1419
dc.identifier.issnEISSN: 2197-8395
dc.identifier.issnISBN: 978-3-7091-9031-9
dc.identifier.issnEISBN: 978-3-7091-9029-6
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27170
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage45
dc.relation.citationStartPage39
dc.relation.citationTitleActa Neurochirurgica;Acta Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8
dc.relation.citationVolumeVol. 46
dc.relation.ispartofActa Neurochirurgica, Supplement, ISSN: 0065-1419; EISSN: 2197-8395, Vol.46 (1989);pp. 39-45spa
dc.relation.ispartofActa Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8, ISBN: 978-3-7091-9031-9 ; EISBN: 978-3-7091-9029-6, Supl.46 (1989); pp. 39-45spa
dc.relation.urihttps://link.springer.com/chapter/10.1007%2F978-3-7091-9029-6_9spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceActa Neurochirurgicaspa
dc.sourceActa Neurochirurgica. Supplementum: Advances in Stereotactic and Functional Neurosurgery 8spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSpasticityspa
dc.subject.keywordIntrathecalspa
dc.subject.keywordBaclofenspa
dc.subject.keywordInfusion pumpspa
dc.titleUse of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.spa
dc.title.TranslatedTitleUso de baclofeno intratecal administrado por bombas de infusión programables en espasticidad resistente.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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