Ítem
Acceso Abierto

Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017

Mostrar el registro sencillo de la publicación
dc.creatorPimentel, Victorspa
dc.creatorPingarilho, Martaspa
dc.creatorAlves, Danielaspa
dc.creatorDiogo, Isabelspa
dc.creatorFernandes, Sandraspa
dc.creatorMiranda, Mafaldaspa
dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorLibin, Pieterspa
dc.creatorMartins, M. Rosário O.spa
dc.creatorVandamme, Anne-Miekespa
dc.creatorCamacho, Ricardo J.spa
dc.creatorGomes, Perpétuaspa
dc.creatorAbecasis, Anaspa
dc.date.accessioned2020-05-26T00:02:22Z
dc.date.available2020-05-26T00:02:22Z
dc.date.created2020spa
dc.description.abstractMigration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) andNucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur. © 2020 by the authors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/v12030268
dc.identifier.issn19994915
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23477
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleViruses
dc.relation.citationVolumeVol. 12
dc.relation.ispartofViruses, ISSN:19994915, Vol.12, No.3 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85080989468&doi=10.3390%2fv12030268&partnerID=40&md5=0512709d5623dfc048fc07877205b6ddspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHIV drug resistance mutationsspa
dc.subject.keywordMigrantsspa
dc.subject.keywordMolecular epidemiologyspa
dc.titleMolecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
viruses-12-00268-v2.pdf
Tamaño:
4.42 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos