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Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorFabre, D.spa
dc.creatorBressolle, F.spa
dc.creatorBologna, C.spa
dc.creatorAlric R.spa
dc.creatorCocciglio, M.spa
dc.date.accessioned2020-08-19T14:42:47Z
dc.date.available2020-08-19T14:42:47Z
dc.date.created1991spa
dc.description.abstractOBJECTIVE: To determine if the pharmacokinetics of methotrexate (MTX) is modified by the coadministration of etodolac. METHODS: MTX (10 mg) was administered intramuscularly in the absence and presence of steady state levels of etodolac in 19 patients with rheumatoid arthritis. MTX levels were assayed by fluorescence polarization immunoassay. Concentrations of 7-hydroxymethotrexate (7-OH-MTX) were assayed by a reverse phase high performance liquid chromatography method. The unbound fraction was determined by ultrafiltration. RESULTS: When etodolac was coadministered with MTX, the highest observed concentration decreased and the mean residence time increased to become statistically significant. However, these differences are not of great clinical importance especially given that the area under the curve and clearances were unchanged. There were no significant differences in binding protein and 7-OH-MTX concentrations between MTX with and without etodolac administration. CONCLUSION: The pharmacokinetics of MTX is slightly modified by coadministration of etodolac. Moreover, no clinical toxicity was observed.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0315-162X
dc.identifier.issnEISSN: 1499-2752
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27572
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage208
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage203
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 21
dc.relation.ispartofJournal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.21, No.2 (31 Enero de 1994); pp. 203-208spa
dc.relation.urihttps://europepmc.org/article/med/8182625spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceJournal of Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPharmacokinetics of methotrexate (MTX)spa
dc.subject.keywordEtodolacspa
dc.subject.keywordLiquid chromatographyspa
dc.titleEffect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritisspa
dc.title.TranslatedTitleEfecto de etodolaco sobre la farmacocinética del metotrexato en pacientes con artritis reumatoidespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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