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Helicobacter pylori serology in autoimmune diseases - Fact or fiction?

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dc.creatorRam, Mayaspa
dc.creatorBarzilai, Orispa
dc.creatorShapira, Yinonspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorTincani, Angelaspa
dc.creatorStojanovich, Ljudmilaspa
dc.creatorBombardieri, Stefanospa
dc.creatorBizzaro, Nicolaspa
dc.creatorKivity, Shayespa
dc.creatorLevin, Nancy Agmonspa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-26T00:04:21Z
dc.date.available2020-05-26T00:04:21Z
dc.date.created2013spa
dc.description.abstractBackground: The pathogenesis of autoimmunity is presumed to be a complex process including genetic predisposition, hormonal balance and environmental factors such as infectious agents . Helicobacter pylori , a common bacterial infectious agent has been associated with a variety of autoimmune disorders. However, this bacteria is also thought to play a protective role in the development of multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD). We tested various links between anti- H. pylori (anti-HP) antibodies and a wide profile of autoimmune diseases and autoantibodies. Methods: A total of 1290 patients diagnosed with 14 different autoimmune diseases from two geographical areas (Europe and Latin America) and two groups of healthy matching controls (n = 385) were screened for the presence of H. pylori IgG antibodies by ' pylori detect ' kit. In parallel, a large profile belonging to three groups of autoantibodies was tested in all sera (anti-nuclear antibodies, autoantibodies associated with thrombophilia and gastrointestinal diseases). Results: Our data demonstrate associations between anti-HP antibodies and anti-phospholipid syndrome, giant cell arteritis, systemic sclerosis and primary biliary cirrhosis. Our data also support a previously known negative association between the prevalence of anti-HP antibodies and IBD. Additionally, links were made between seropositivity to H. pylori and the presence of anti-nuclear antibodies, dsDNA, anti-Ro and some thrombophiliaassociated antibodies, as well as negative associations with gastrointestinal-associated antibodies. Conclusions: Whether these links are epiphenomenal or H. pylori does play a causative role in the autoimmune diseases remains uncertain. The negative associations could possibly support the notion that in susceptible individuals infections may protect from the development of autoimmune diseases.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1515/cclm-2012-0477
dc.identifier.issn14346621
dc.identifier.issn14374331
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23678
dc.language.isoengspa
dc.relation.citationEndPage1082
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage1075
dc.relation.citationTitleClinical Chemistry and Laboratory Medicine
dc.relation.citationVolumeVol. 51
dc.relation.ispartofClinical Chemistry and Laboratory Medicine, ISSN:14346621, 14374331, Vol.51, No.5 (2013); pp. 1075-1082spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84882282125&doi=10.1515%2fcclm-2012-0477&partnerID=40&md5=864595c1b8789a76a206d06f3efc954aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordbacterialeng
dc.subject.keywordAutoantibodyspa
dc.subject.keywordDouble stranded dnaspa
dc.subject.keywordImmunoglobulin g antibodyspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordControlled studyspa
dc.subject.keywordGastrointestinal diseasespa
dc.subject.keywordGiant cell arteritisspa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordHumanspa
dc.subject.keywordInfectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSerologyspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordThrombophiliaspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntigen-antibody reactionsspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordBlood chemical analysisspa
dc.subject.keywordHelicobacter infectionsspa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordHumansspa
dc.subject.keywordAntibodiesspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordInfectionspa
dc.titleHelicobacter pylori serology in autoimmune diseases - Fact or fiction?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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