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Specific interaction between mycobacterium tuberculosis lipoprotein-derived peptides and target cells inhibits Mycobacterial entry in vitro

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dc.creatorOcampo, Marisol
dc.creatorCurtidor, Hernandospa
dc.creatorVanegas, Magnoliaspa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:04:02Z
dc.date.available2020-05-26T00:04:02Z
dc.date.created2014spa
dc.description.abstractTuberculosis (TB) continues being one of the diseases having the greatest mortality rates around the world, 8.7 million cases having been reported in 2011. An efficient vaccine against TB having a great impact on public health is an urgent need. Usually, selecting antigens for vaccines has been based on proteins having immunogenic properties for patients suffering TB and having had promising results in mice and non-human primates. Our approach has been based on a functional approach involving the pathogen-host interaction in the search for antigens to be included in designing an efficient, minimal, subunit-based anti-TB vaccine. This means that Mycobacterium tuberculosis has mainly been involved in studies and that lipoproteins represent an important kind of protein on the cell envelope which can also contribute towards this pathogen's virulence. This study has assessed the expression of four lipoproteins from M. tuberculosis H37Rv, that is, Rv1411c (LprG), Rv1911c (LppC), Rv2270 (LppN) and Rv3763 (LpqH), and the possible biological activity of peptides derived from these. Five peptides were found for these proteins which had high specific binding to both alveolar A549 epithelial cells and U937 monocyte-derived macrophages which were able to significantly inhibit mycobacterial entry to these cells in vitro. © 2014 John Wiley and Sons A/S.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/cbdd.12365
dc.identifier.issn17470277
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23650
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage641
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage626
dc.relation.citationTitleChemical Biology and Drug Design
dc.relation.citationVolumeVol. 84
dc.relation.ispartofChemical Biology and Drug Design, ISSN:17470277, Vol.84, No.6 (2014); pp. 626-641spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84915819376&doi=10.1111%2fcbdd.12365&partnerID=40&md5=0573841866c487b00b4657ecd9f2db97spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBCG vaccinespa
dc.subject.keywordTumoreng
dc.subject.keywordMycobacterium tuberculosis lipoprotein Rv1411cspa
dc.subject.keywordMycobacterium tuberculosis lipoprotein Rv1911cspa
dc.subject.keywordMycobacterium tuberculosis lipoprotein Rv2270spa
dc.subject.keywordMycobacterium tuberculosis lipoprotein Rv3763spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAntibodyspa
dc.subject.keywordBacterial proteinspa
dc.subject.keywordLipoproteinspa
dc.subject.keywordMicrospherespa
dc.subject.keywordPeptidespa
dc.subject.keywordProtein bindingspa
dc.subject.keywordA549 cell linespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordArticlespa
dc.subject.keywordBacterial membranespa
dc.subject.keywordBacterial virulencespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEpithelium cellspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordIn vitro studyspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordProtein localizationspa
dc.subject.keywordProtein structurespa
dc.subject.keywordTarget cellspa
dc.subject.keywordU937 cell linespa
dc.subject.keywordBiologyspa
dc.subject.keywordChemistryspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMetabolismspa
dc.subject.keywordMolecular geneticsspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordProtein secondary structurespa
dc.subject.keywordSynthesisspa
dc.subject.keywordTumor cell linespa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordAmino Acid Sequencespa
dc.subject.keywordAntibodiesspa
dc.subject.keywordBacterial Proteinsspa
dc.subject.keywordCell Lineeng
dc.subject.keywordComputational Biologyspa
dc.subject.keywordHost-Pathogen Interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordLipoproteinsspa
dc.subject.keywordMicrospheresspa
dc.subject.keywordMolecular Sequence Dataspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordPeptidesspa
dc.subject.keywordProtein Bindingspa
dc.subject.keywordProtein Structureeng
dc.subject.keywordU937 Cellsspa
dc.subject.keywordAntituberculosis vaccinespa
dc.subject.keywordHigh activity binding peptidespa
dc.subject.keywordMulti-epitope vaccinespa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordSynthetic peptidespa
dc.titleSpecific interaction between mycobacterium tuberculosis lipoprotein-derived peptides and target cells inhibits Mycobacterial entry in vitrospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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