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The Plasmodium vivax Pv41 surface protein: Identification and characterization

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dc.creatorAngel, Diana I.spa
dc.creatorMongui, Alvarospa
dc.creatorArdila-Montealegre, Javier
dc.creatorVanegas, Magnoliaspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:02:34Z
dc.date.available2020-05-26T00:02:34Z
dc.date.created2008spa
dc.description.abstractRecently, Plasmodium vivax has been related to nearly 81% of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. © 2008 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2008.10.129
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23503
dc.language.isoengspa
dc.relation.citationEndPage1117
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage1113
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 377
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.377, No.4 (2008); pp. 1113-1117spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-56349090489&doi=10.1016%2fj.bbrc.2008.10.129&partnerID=40&md5=2dcf940f872febf2803087c367924603spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordmoleculareng
dc.subject.keywordMembrane proteinspa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordArticlespa
dc.subject.keywordBioinformaticsspa
dc.subject.keywordCellular distributionspa
dc.subject.keywordData basespa
dc.subject.keywordExonspa
dc.subject.keywordGametocytespa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordLife cyclespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein determinationspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordCell membranespa
dc.subject.keywordCloningeng
dc.subject.keywordErythrocytesspa
dc.subject.keywordExonsspa
dc.subject.keywordMembrane proteinsspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtein structureeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordRabbitsspa
dc.subject.keywordTranscriptioneng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordBioinformaticsspa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPv41spa
dc.subject.keywordSix-cys domainspa
dc.subject.keywordVaccine candidatespa
dc.titleThe Plasmodium vivax Pv41 surface protein: Identification and characterizationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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