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Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.

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dc.creatorRuiz-Garzon, Jair Antoniospa
dc.creatorRojas-Velandia, Camilo Andrésspa
dc.creatorCalderón Ospina, Carlos Albertospa
dc.date.accessioned2020-06-11T13:20:57Z
dc.date.available2020-06-11T13:20:57Z
dc.date.created2019spa
dc.description.abstractObjective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cross-sectional observational study. Clinical records of patients who arrived at the emergency service of a third-care level university hospital were reviewed. Information was collected by a resident in clinical toxicology, and each case was validated and analyzed by a research team using the algorithm proposed by Vaca Gonzalez and Schumock and Thornton criteria for preventability to evaluate the existence of possible medication errors. Findings: In total, 697 clinical records were evaluated and 18 patients presented TFs (2.6%, 95% confidence interval 1.5%-4.1%) as the cause of admission to the ICU. The most frequent TFs were seizures (56%) and hypertension (28%). The most commonly associated medications were valproic acid (28%) and losartan (28%). Ten cases (56%) were associated with drug misuse and the same number of cases was preventable, according to Schumock and Thornton criteria. Conclusion: This is the first study assessing TFs as a cause of admission to the ICU in the Colombian population. The frequency of TFs in our study was similar to that described in the literature; being the most common cause the inappropriate drug use, particularly for drugs with complex kinetics, such as antiepileptic drugs.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4103/jrpp.jrpp_18_69
dc.identifier.issn2319-9644
dc.identifier.issn2279-042X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24647
dc.language.isoeng
dc.publisherJournal of Research in Pharmacy Practicespa
dc.relation.citationEndPage172
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage168
dc.relation.citationTitleJournal of Research in Pharmacy Practice
dc.relation.citationVolumeVol. 8
dc.relation.ispartofJournal of Research in Pharmacy Practice, ISSN: 2319-9644;2279-042X, Vol.8, No.3 (2019); pp. 168-172spa
dc.relation.urihttps://doi.org/10.4103/jrpp.jrpp_18_69spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDrug-related side effects and adverse reactionsspa
dc.subject.keywordintensive care unitsspa
dc.subject.keywordpatient admissionsspa
dc.subject.keywordpharmacovigilancespa
dc.subject.keywordpostmarketingspa
dc.subject.keywordproduct surveillancespa
dc.titleDrug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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