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Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development

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dc.creatorPatarroyo M.E.spa
dc.creatorBermúdez A.spa
dc.creatorPatarroyo M.A.spa
dc.date.accessioned2020-05-26T00:04:04Z
dc.date.available2020-05-26T00:04:04Z
dc.date.created2011spa
dc.description.abstractIdentifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1021/cr100223m
dc.identifier.issn15206890
dc.identifier.issn00092665
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23654
dc.language.isoengspa
dc.relation.citationEndPage3507
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage3459
dc.relation.citationTitleChemical Reviews
dc.relation.citationVolumeVol. 111
dc.relation.ispartofChemical Reviews, ISSN:15206890, 00092665, Vol.111, No.5 (2011); pp. 3459-3507spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79955897554&doi=10.1021%2fcr100223m&partnerID=40&md5=f90047bb18e44c278ecf94806db0d21bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordClass Ispa
dc.subject.keywordSubuniteng
dc.subject.keywordCytokinesspa
dc.subject.keywordFalciparum malariaspa
dc.subject.keywordGenes encodingspa
dc.subject.keywordHepatic cellsspa
dc.subject.keywordHigh affinityspa
dc.subject.keywordImmune systemsspa
dc.subject.keywordMolecular levelsspa
dc.subject.keywordVaccine developmentspa
dc.subject.keywordBiosynthesisspa
dc.subject.keywordCloningspa
dc.subject.keywordGenesspa
dc.subject.keywordVaccinesspa
dc.subject.keywordSubunit vaccinespa
dc.subject.keywordVaccinespa
dc.subject.keywordChemical structurespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunizationspa
dc.subject.keywordImmunologyspa
dc.subject.keywordReviewspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunizationspa
dc.subject.keywordModelseng
dc.subject.keywordVaccinesspa
dc.subject.keywordVaccineseng
dc.titleStructural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine developmentspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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