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Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice

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dc.creatorKatzav, Avivaspa
dc.creatorArango, Maria T.spa
dc.creatorKivity, Shayespa
dc.creatorTanaka, Susumuspa
dc.creatorGivaty, Gilispa
dc.creatorAgmon-Levin, Nancyspa
dc.creatorHonda, Makotospa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorChapman, Joabspa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:55:54Z
dc.date.available2020-05-25T23:55:54Z
dc.date.created2013spa
dc.description.abstractNarcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy (a sudden weakening of posture muscle tone usually triggered by emotion) caused by the loss of orexin neurons in the hypothalamus. Autoimmune mechanisms are implicated in narcolepsy by increased frequency of specific HLA alleles and the presence of specific autoantibody (anti-Tribbles homolog 2 (TRIB2) antibodies) in the sera of patients with narcolepsy. Presently, we passively transferred narcolepsy to naïve mice by injecting intra-cerebra-ventricularly (ICV) pooled IgG positive for anti-TRIB2 antibodies. Narcolepsy-IgG-injected mice had a loss of the NeuN (neuronal marker), synaptophysin (synaptic marker) and orexin-positive neurons in the lateral hypothalamus area in narcolepsy compared to control-IgG-injected mice and these changes were associated with narcolepsy-like immobility attacks at four weeks post injection and with hyperactivity and long term memory deficits in the staircase and novel object recognition tests. Similar behavioral and cognitive deficits are observed in narcoleptic patients. This is the first report of passive transfer of experimental narcolepsy to naïve mice induced by autoantibodies and supports the autoimmune pathogenesis in narcolepsy. © 2013 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2013.06.010
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22254
dc.language.isoengspa
dc.relation.citationEndPage30
dc.relation.citationStartPage24
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 45
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.45,(2013); pp. 24-30spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84884287135&doi=10.1016%2fj.jaut.2013.06.010&partnerID=40&md5=13176cc5d87b29c33233d4f0b9fac002spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordpassiveeng
dc.subject.keywordinbred c3heng
dc.subject.keywordBiological markerspa
dc.subject.keywordanimaleng
dc.subject.keywordphysiologicaleng
dc.subject.keywordHla antibodyspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordNeuron specific nuclear proteinspa
dc.subject.keywordOrexinspa
dc.subject.keywordSynaptophysinspa
dc.subject.keywordTrib2 autoantibodyspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBrain regionspa
dc.subject.keywordCataplexyspa
dc.subject.keywordCognitive defectspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDaytime somnolencespa
dc.subject.keywordHumanspa
dc.subject.keywordHyperactivityspa
dc.subject.keywordHypothalamusspa
dc.subject.keywordImmobilizationspa
dc.subject.keywordLong term memoryspa
dc.subject.keywordMousespa
dc.subject.keywordNarcolepsyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNormal humanspa
dc.subject.keywordPassive transportspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRecognitionspa
dc.subject.keywordSleepspa
dc.subject.keywordAnti-tribbles homolog 2 (trib2) antibodiesspa
dc.subject.keywordBehavioral deficitsspa
dc.subject.keywordNarcolepsyspa
dc.subject.keywordOrexinspa
dc.subject.keywordPassive transferspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordCataplexyspa
dc.subject.keywordCell deathspa
dc.subject.keywordDisease modelseng
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordHypothalamusspa
dc.subject.keywordImmunizationeng
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordIntracellular signaling peptides and proteinsspa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordNarcolepsyspa
dc.subject.keywordNeuronsspa
dc.subject.keywordNeuropeptidesspa
dc.subject.keywordPattern recognitioneng
dc.subject.keywordAnti-tribbles homolog 2 (trib2) antibodiesspa
dc.subject.keywordBehavioral deficitsspa
dc.subject.keywordNarcolepsyspa
dc.subject.keywordOrexinspa
dc.subject.keywordPassive transferspa
dc.titlePassive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in micespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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