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Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia

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dc.creatorDucat, Aurélienspa
dc.creatorDoridot, Ludivinespa
dc.creatorCalicchio, Rosamariaspa
dc.creatorMéhats, Celinespa
dc.creatorVilotte, Jean-Lucspa
dc.creatorCastille, Johannspa
dc.creatorBarbaux, Sandrinespa
dc.creatorCouderc, Bettyspa
dc.creatorJacques, Sébastienspa
dc.creatorLetourneur, Franckspa
dc.creatorBuffat, Christophespa
dc.creatorLe Grand, Fabienspa
dc.creatorLaissue, Paulspa
dc.creatorMiralles, Franciscospa
dc.creatorVaiman, Danielspa
dc.date.accessioned2020-05-26T00:00:53Z
dc.date.available2020-05-26T00:00:53Z
dc.date.created2016spa
dc.description.abstractPreeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression. Using Next Generation Sequencing on endothelial cells of mice carrying either transgenic or control embryos, we discovered significant alterations of gene networks involved in inflammation, cell cycle, and cardiac hypertrophy. In addition, the heart of the preeclamptic mice revealed cardiac hypertrophy associated with histological anomalies. Bioinformatics comparison of the networks of modified genes in the endothelial cells of the preeclamptic mice and HUVECs exposed to plasma from preeclamptic women identified striking similarities. The cardiovascular alterations in the pregnant mice are comparable to those endured by the cardiovascular system of preeclamptic women. The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/srep19196
dc.identifier.issn20452322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23283
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationTitleScientific Reports
dc.relation.citationVolumeVol. 6
dc.relation.ispartofScientific Reports, ISSN:20452322, Vol.6,(2016)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84955091391&doi=10.1038%2fsrep19196&partnerID=40&md5=12c2c62569e7b1484a5999b606c980a5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCarrier proteinspa
dc.subject.keywordhumaneng
dc.subject.keywordStox1 proteineng
dc.subject.keywordTranscriptomespa
dc.subject.keywordAnimalspa
dc.subject.keywordCardiomegalyspa
dc.subject.keywordCell linespa
dc.subject.keywordCluster analysisspa
dc.subject.keywordDisease modelspa
dc.subject.keywordEndothelium cellspa
dc.subject.keywordFemalespa
dc.subject.keywordGene expression profilingspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGene regulatory networkspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHumanspa
dc.subject.keywordMetabolismspa
dc.subject.keywordMortalityspa
dc.subject.keywordMousespa
dc.subject.keywordPathologyspa
dc.subject.keywordPreeclampsiaspa
dc.subject.keywordPregnancyspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordTransgenic mousespa
dc.subject.keywordAnimalsspa
dc.subject.keywordCardiomegalyspa
dc.subject.keywordCarrier proteinsspa
dc.subject.keywordCell linespa
dc.subject.keywordCluster analysisspa
dc.subject.keywordDisease modelseng
dc.subject.keywordEndothelial cellsspa
dc.subject.keywordFemalespa
dc.subject.keywordGene expression profilingspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGene regulatory networksspa
dc.subject.keywordHumansspa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordPre-eclampsiaspa
dc.subject.keywordPregnancyspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein interaction mappingspa
dc.subject.keywordProtein interaction mapsspa
dc.subject.keywordTranscriptomespa
dc.titleEndothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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