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Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans

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dc.creatorSuárez C.F.spa
dc.creatorPabón L.spa
dc.creatorBarrera A.spa
dc.creatorAza-Conde J.spa
dc.creatorPatarroyo M.A.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-26T00:02:43Z
dc.date.available2020-05-26T00:02:43Z
dc.date.created2017spa
dc.description.abstractMore than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainly antibody-mediated and controlled by the HLA-DRB genetic region, ?1000 Aotus have been molecularly characterised for MHC-DRB, revealing striking similarity between human and Aotus MHC-DRB repertories. Such convergence suggested that a large group of immune protection-inducing protein structures (IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge in Aotus, could easily be used in humans for inducing full protection against malaria. We highlight the value of a logical and rational methodology for developing a vaccine in an appropriate animal model: Aotus monkeys. © 2017 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2017.08.012
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23518
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage1069
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage1062
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 491
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.491, No.4 (2017); pp. 1062-1069spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85027277802&doi=10.1016%2fj.bbrc.2017.08.012&partnerID=40&md5=1b77f83d10ac657442da298c3bea31f8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA DRB1 antigenspa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordHLA antigen class 2spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordAotusspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordHydrophobicityspa
dc.subject.keywordImmunofluorescence testspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProton nuclear magnetic resonancespa
dc.subject.keywordStatic electricityspa
dc.subject.keywordVaccinationspa
dc.subject.keywordWestern blottingspa
dc.subject.keywordAnimalspa
dc.subject.keywordAntigen antibody reactionspa
dc.subject.keywordAotidaespa
dc.subject.keywordChemistryspa
dc.subject.keywordImmunologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigen-Antibody Reactionsspa
dc.subject.keywordAotidaespa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria Vaccinesspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordHLA-peptide bindingspa
dc.subject.keywordIMPIPSspa
dc.subject.keywordMalarial-vaccinespa
dc.subject.keywordMHC-DRspa
dc.titleStructural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humansspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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