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Synthetic peptides from conserved regions of the Plasmodium falciparum early transcribed membrane and ring exported proteins bind specifically to red blood cell proteins

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dc.creatorGarcia, Jeisonspa
dc.creatorCurtidor, Hernandospa
dc.creatorObando-Martinez, Ana Z.spa
dc.creatorVizcaíno, Carolinaspa
dc.creatorPinto, Marthaspa
dc.creatorMartinez, Nora L.spa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:02:09Z
dc.date.available2020-05-26T00:02:09Z
dc.date.created2009spa
dc.description.abstractSevere malaria pathology is directly associated with cytoadherence of infected red blood cells (iRBCs) to healthy RBCs and/or endothelial cells occurring during the intraerythrocytic development of Plasmodium falciparum. We synthesized, as 20-mer long peptides, the members of the ring exported (REX) protein family encoded in chromosome 9, as well as the early transcribed membrane proteins (E-TRAMP) 10.2 and 4, to identify specific RBC binding regions in these proteins. Twelve binding peptides were identified (designated as HABPs): three were identified in REX1, two in REX2, one in REX3, two in REX4 and four in E-TRAMP 10.2. The majority of these HABPs was conserved among different P. falciparum strains, according to sequence analysis. No HABPs were found in E-TRAMP 4. Bindings of HABPs were saturable and sensitive to the enzymatic treatment of RBCs and HABPs had different structural features, according to circular dichroism studies. Our results suggest that the REX and E-TRAMP families participate in relevant interactions with RBC membrane proteins, which highlight these proteins as potential targets for the development of fully effective immunoprophylactic methods. © 2009 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2009.09.009
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23452
dc.language.isoengspa
dc.relation.citationEndPage6886
dc.relation.citationIssueNo. 49
dc.relation.citationStartPage6877
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 27
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.27, No.49 (2009); pp. 6877-6886spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70350568722&doi=10.1016%2fj.vaccine.2009.09.009&partnerID=40&md5=552a890e5993bafb92fdd3b0661c4677spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEarly transcribed membrane protein 10.2spa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordRex proteinspa
dc.subject.keywordRex1 proteinspa
dc.subject.keywordRex2 proteinspa
dc.subject.keywordRex3 proteinspa
dc.subject.keywordRex4 proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordChromosome 9spa
dc.subject.keywordCircular dichroismspa
dc.subject.keywordControlled studyspa
dc.subject.keywordErythrocytespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunoprophylaxisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPeptide synthesisspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordDnaeng
dc.subject.keywordErythrocyte membranespa
dc.subject.keywordErythrocytesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordAntimalarial vaccinespa
dc.subject.keywordE-trampspa
dc.subject.keywordEarly transcribed membrane proteinspa
dc.subject.keywordHabpsspa
dc.subject.keywordHigh activity binding peptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordRexspa
dc.subject.keywordRing exported proteinspa
dc.titleSynthetic peptides from conserved regions of the Plasmodium falciparum early transcribed membrane and ring exported proteins bind specifically to red blood cell proteinsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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