Ítem
Solo Metadatos

The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development

Mostrar el registro sencillo de la publicación
dc.creatorReyes C.spa
dc.creatorMoreno-Vranich A.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-26T00:02:42Z
dc.date.available2020-05-26T00:02:42Z
dc.date.created2017spa
dc.description.abstractAnalysis of our Plasmodium falciparum malaria parasite peptides’ 1H-NMR database in the search for H-bonds and ?-interactions led us to correlate their presence or absence with a peptide's particular immunological behavior. It was concluded that a 26.5 ± 1.5 Å between positions 1 to 9 of the HLA-DR?1* interacting region was necessary for proper docking of 20mer-long peptides and these MHC Class II molecules for full-protective immunity. Presence of intramolecular H-bonds or ?-interactions leading to righ-handed ?-helix or ?-turn conformation in this peptide's region induces different immune responses or none. PPIIL conformation and the absence of any intramolecular interaction thus became the first feature characterising our immune protection-inducing structures as malaria vaccine candidates. © 2017 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2017.01.077
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23516
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage507
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage501
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 484
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.484, No.3 (2017); pp. 501-507spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85011030545&doi=10.1016%2fj.bbrc.2017.01.077&partnerID=40&md5=55d439795794ba2c0d2eb1624b7bc159spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA DRB1 antigenspa
dc.subject.keywordSyntheticeng
dc.subject.keywordHLA antigen class 2spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordPeptidespa
dc.subject.keywordProtein bindingspa
dc.subject.keywordRecombinant vaccinespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAotusspa
dc.subject.keywordArticlespa
dc.subject.keywordConformationspa
dc.subject.keywordForcespa
dc.subject.keywordHydrogen bondspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunityspa
dc.subject.keywordImmunofluorescencespa
dc.subject.keywordMajor histocompatibility complexspa
dc.subject.keywordMolecular dockingspa
dc.subject.keywordMolecular interactionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPeptide synthesisspa
dc.subject.keywordPhspa
dc.subject.keywordPi interactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProton nuclear magnetic resonancespa
dc.subject.keywordStatic electricityspa
dc.subject.keywordBinding sitespa
dc.subject.keywordChemistryspa
dc.subject.keywordDrug designspa
dc.subject.keywordHydrogen bondspa
dc.subject.keywordProceduresspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein conformationspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordStructure activity relationspa
dc.subject.keywordUltrastructurespa
dc.subject.keywordBinding Sitesspa
dc.subject.keywordDrug Designspa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHLA-DRB1 Chainsspa
dc.subject.keywordHydrogen Bondingspa
dc.subject.keywordMalaria Vaccinesspa
dc.subject.keywordPeptidesspa
dc.subject.keywordProtein Bindingspa
dc.subject.keywordProtein Conformationspa
dc.subject.keywordProtein Interaction Mappingspa
dc.subject.keywordSequence Analysiseng
dc.subject.keywordStructure-Activity Relationshipspa
dc.subject.keywordVaccineseng
dc.subject.keywordHydrogen bondspa
dc.subject.keywordMalariaspa
dc.subject.keywordTCR-peptide-MHC complexspa
dc.subject.keywordX—H-? interactionspa
dc.titleThe role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine developmentspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos