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Polymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American setting

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dc.creatorGómez Marín J.E.spa
dc.creatorZuluaga J.D.spa
dc.creatorPechené Campo E.J.spa
dc.creatorTriviño J.spa
dc.creatorde-la-Torre, Alejandraspa
dc.date.accessioned2020-05-26T00:04:36Z
dc.date.available2020-05-26T00:04:36Z
dc.date.created2018spa
dc.description.abstractIntroduction: Cases of toxoplasmosis present in South America tend to be more severe than that found in other continents. Here, we present our clinical experience of ocular and ganglionar toxoplasmosis in the use of PCR, and of the treatment to prevent ocular involvement. Methodology: Retrospective analysis of clinical charts of patients with ocular and lymphadenitic toxoplasmosis at the parasitology and tropical medicine consultation in the “Universidad del Quindio” in Colombia. In total, 91 records of cases with ocular toxoplasmosis and 17 with lymphadenitis that underwent PCR analysis for B1 repeated sequence in blood, were compared to the results of 104 people with chronic asymptomatic toxoplasmosis. In addition, 41 clinical records were included from patients with confirmed toxoplasmic lymphadenitis: 10 untreated, 6 that begun treatment after four months of symptoms, and 25 that were treated during the first four months of symptoms and had a follow-up during at least one year. Results: Patients with ocular toxoplasmosis or lymphadenitis had a higher probability of PCR positivity in peripheral blood than chronic asymptomatic people. There were no cases of retinochoroiditis in 25 patients with toxoplasmic lymphadenitis treated before 4 months of symptoms and followed during at least 12 months. In four out of ten untreated cases, new lesions of retinochoroiditis presented after the symptoms of lymphadenitis. Conclusions: Toxoplasmosisin South America exhibits different clinical behavior and this influences the laboratory results as well as the need for treatment in the case of lymphadenitis. Clinicians should be aware of the geographical origin of the infection in order to adopt different therapeutic and diagnostic approaches. © 2018 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2018.01.013
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23697
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage87
dc.relation.citationStartPage83
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 184
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.184,(2018); pp. 83-87spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042003376&doi=10.1016%2fj.actatropica.2018.01.013&partnerID=40&md5=187e6c129f3c3c3eb9a4c78151d61573spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordClindamycinspa
dc.subject.keywordCotrimoxazolespa
dc.subject.keywordoculareng
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordPrednisolonespa
dc.subject.keywordPyrimethaminespa
dc.subject.keywordPyrimethamine plus sulfadoxinespa
dc.subject.keywordSulfadoxinespa
dc.subject.keywordSulfamethoxazolespa
dc.subject.keywordTrimethoprimspa
dc.subject.keywordDeveloping worldspa
dc.subject.keywordDisease treatmentspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordEye diseasespa
dc.subject.keywordInfectious diseasespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAmericanspa
dc.subject.keywordArticlespa
dc.subject.keywordAsymptomatic diseasespa
dc.subject.keywordBest corrected visual acuityspa
dc.subject.keywordBlood analysisspa
dc.subject.keywordBlurred visionspa
dc.subject.keywordCervical lymphadenopathyspa
dc.subject.keywordChildspa
dc.subject.keywordChillspa
dc.subject.keywordChorioretinitisspa
dc.subject.keywordColombiaspa
dc.subject.keywordComparative studyspa
dc.subject.keywordConsultationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiarrheaspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordEpiretinal membranespa
dc.subject.keywordFemalespa
dc.subject.keywordFeverspa
dc.subject.keywordFollow upspa
dc.subject.keywordGanglionar toxoplasmosisspa
dc.subject.keywordHumanspa
dc.subject.keywordIridotomyspa
dc.subject.keywordLymphadenitisspa
dc.subject.keywordLymphadenopathyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMedical historyspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordOphthalmoscopyspa
dc.subject.keywordOptic diskspa
dc.subject.keywordPersonal experiencespa
dc.subject.keywordPhysical examinationspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrimary preventionspa
dc.subject.keywordRetina detachmentspa
dc.subject.keywordRetina macula cystoid edemaspa
dc.subject.keywordRetinitisspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordSymptomspa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordTreatment durationspa
dc.subject.keywordTropical medicinespa
dc.subject.keywordVery elderlyspa
dc.subject.keywordVisual acuityspa
dc.subject.keywordVitreous body detachmentspa
dc.subject.keywordVitritisspa
dc.subject.keywordVomitingspa
dc.subject.keywordGanglion cystspa
dc.subject.keywordGeneticsspa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordLymphadenitisspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordProceduresspa
dc.subject.keywordColombiaspa
dc.subject.keywordAdultspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGanglion cystsspa
dc.subject.keywordHumansspa
dc.subject.keywordLymphadenitisspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordRetrospective studiesspa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordToxoplasmosiseng
dc.subject.keywordColombiaspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordToxoplasmic lymphadenitisspa
dc.subject.keywordUveitisspa
dc.titlePolymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American settingspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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