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GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s disease

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dc.contributor.gruplacGrupo de Investigación de Neurociencias de la Universidad del Rosario (NEUROS)spa
dc.creatorNava Mesa, Mauricio Orlando
dc.creatorJiménez-Díaz, Lydia
dc.creatorYajeya, Javier
dc.creatorNavarro-Lopez, Juan D.
dc.creator.googleNava-Mesa, Mauricio O.spa
dc.creator.googleJiménez-Díaz, Lydiaspa
dc.creator.googleYajeya, Javierspa
dc.creator.googleNavarro-Lopez, Juan D.spa
dc.date.accessioned2019-05-06T14:56:03Z
dc.date.available2019-05-06T14:56:03Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two pathological lesions: extracellular amyloid plaques, composed largely of amyloid-beta peptide (Aβ), and neurofibrillary tangles formed by intracellular aggregates of hyperphosphorylated tau protein. Lesions mainly accumulate in brain regions that modulate cognitive functions such as the hippocampus, septum or amygdala. These brain structures have dense reciprocal glutamatergic, cholinergic, and GABAergic connections and their relationships directly affect learning and memory processes, so they have been proposed as highly susceptible regions to suffer damage by Aβ during AD course. Last findings support the emerging concept that soluble Aβ peptides, inducing an initial stage of synaptic dysfunction which probably starts 20–30 years before the clinical onset of AD, can perturb the excitatory–inhibitory balance of neural circuitries. In turn, neurotransmission imbalance will result in altered network activity that might be responsible of cognitive deficits in AD. Therefore, Aβ interactions on neurotransmission systems in memory-related brain regions such as amygdaloid complex, medial septum or hippocampus are critical in cognitive functions and appear as a pivotal target for drug design to improve learning and dysfunctions that manifest with age. Since treatments based on glutamatergic and cholinergic pharmacology in AD have shown limited success, therapies combining modulators of different neurotransmission systems including recent findings regarding the GABAergic system, emerge as a more useful tool for the treatment, and overall prevention, of this dementia. In this review, focused on inhibitory systems, we will analyze pharmacological strategies to compensate neurotransmission imbalance that might be considered as potential therapeutic interventions in AD.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fncel.2014.00167
dc.identifier.issn1662-5102
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19571
dc.language.isoengspa
dc.relation.citationEndPage19
dc.relation.citationStartPage1
dc.relation.citationTitleFrontiers in Cellular Neuroscience
dc.relation.citationVolumeVol. 8
dc.relation.ispartofFrontiers in Cellular Neuroscience, ISSN: 1662-5102, Vol. 8 Article 167 (2014), pp 1-19spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fncel.2014.00167/fullspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://www.sherpa.ac.uk/romeo/search.php?issn=1662-5102&la=es
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectseptohippocampal systemspa
dc.subjectamyloid-β peptidespa
dc.subjectexcitatory and inhibitory neurotransmissionspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembSistema Septohipocampalspa
dc.subject.lembPéptido amiloide βspa
dc.subject.lembNeurotransmisión excitatoria e inhibitoriaspa
dc.titleGABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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