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Naloxone facilitates appetitive extinction and eliminates escape from frustration

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dc.creatorNorris, Jacob N.spa
dc.creatorPérez Acosta, Andrés Manuelspa
dc.creatorOrtega, Leonardo A.spa
dc.creatorPapini, Mauricio R.spa
dc.date.accessioned2020-05-25T23:58:05Z
dc.date.available2020-05-25T23:58:05Z
dc.date.created2009spa
dc.description.abstractTwo experiments tested the effects of opioid receptor blockage on behavior. In Experiment 1, rats reinforced for lever pressing with either sucrose or food pellets received treatment with saline, 2, and 10 mg/kg naloxone, i.p. (within-subject design). Naloxone 10 mg/kg increased response latency, but 2 mg/kg had no effect. When shifted to extinction (between-group design), naloxone (2 and 10 mg/kg) facilitated extinction relative to saline animals, after reinforcement with either sucrose or food pellets. In Experiment 2, after 10 sessions of access to 32% sucrose or an empty tube (between-group design), all rats were exposed to the empty tube while allowing them to jump over a barrier into a different compartment. Escape latencies were shorter for downshifted saline than for saline rats always given access to the empty tube. This escape-from-frustration effect was eliminated by naloxone (2 mg/kg, i.p.). Opioid blockage appears to reduce the value of alternative incentives. © 2009 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.pbb.2009.07.012
dc.identifier.issn913057
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22799
dc.language.isoengspa
dc.relation.citationEndPage87
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage81
dc.relation.citationTitlePharmacology Biochemistry and Behavior
dc.relation.citationVolumeVol. 94
dc.relation.ispartofPharmacology Biochemistry and Behavior, ISSN:913057, Vol.94, No.1 (2009); pp. 81-87spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70349263259&doi=10.1016%2fj.pbb.2009.07.012&partnerID=40&md5=e91d34a90093db95178de617b3eb743fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordNaloxonespa
dc.subject.keyworddrugeng
dc.subject.keywordpsychologicaleng
dc.subject.keywordoperanteng
dc.subject.keywordlong-evanseng
dc.subject.keywordanimaleng
dc.subject.keywordOpiate receptorspa
dc.subject.keywordSodium chloridespa
dc.subject.keywordSucrosespa
dc.subject.keywordAnimal behaviorspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAppetitespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEscape behaviorspa
dc.subject.keywordFood intakespa
dc.subject.keywordFrustrationspa
dc.subject.keywordJumpingspa
dc.subject.keywordLatent periodspa
dc.subject.keywordMalespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRatspa
dc.subject.keywordReceptor blockingspa
dc.subject.keywordReinforcementspa
dc.subject.keywordRunningspa
dc.subject.keywordTask performancespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAppetitive behaviorspa
dc.subject.keywordBehavioreng
dc.subject.keywordConditioningeng
dc.subject.keywordDose-response relationshipeng
dc.subject.keywordEscape reactionspa
dc.subject.keywordExtinctioneng
dc.subject.keywordFood deprivationspa
dc.subject.keywordFrustrationspa
dc.subject.keywordMalespa
dc.subject.keywordMatched-pair analysisspa
dc.subject.keywordNaloxonespa
dc.subject.keywordNarcotic antagonistsspa
dc.subject.keywordRatsspa
dc.subject.keywordRatseng
dc.subject.keywordReaction timespa
dc.subject.keywordReinforcement schedulespa
dc.subject.keywordTime factorsspa
dc.subject.keywordAnimaliaspa
dc.subject.keywordRattusspa
dc.subject.keywordEscape-from-frustration effectspa
dc.subject.keywordIncentive downshiftspa
dc.subject.keywordInstrumental extinctionspa
dc.subject.keywordNaloxonespa
dc.subject.keywordOpioid blockagespa
dc.subject.keywordRatsspa
dc.titleNaloxone facilitates appetitive extinction and eliminates escape from frustrationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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