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Natural selection and genetic diversity in the butterfly heliconius melpomene

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dc.creatorMartin, Simon Hspa
dc.creatorMöst, Markusspa
dc.creatorPalmer, William Jspa
dc.creatorSalazar, Camilospa
dc.creatorMcMillan, W Owenspa
dc.creatorJiggins, Francis Mspa
dc.creatorJiggins, Chris Dspa
dc.date.accessioned2020-05-26T00:09:17Z
dc.date.available2020-05-26T00:09:17Z
dc.date.created2016spa
dc.description.abstractA combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila. A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects. © 2016 by the Genetics Society of America.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1534/genetics.115.183285
dc.identifier.issn19432631
dc.identifier.issn00166731
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24149
dc.language.isoengspa
dc.publisherGeneticsspa
dc.relation.citationEndPage541
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage525
dc.relation.citationTitleGenetics
dc.relation.citationVolumeVol. 203
dc.relation.ispartofGenetics, ISSN:19432631, 00166731, Vol.203, No.1 (2016); pp. 525-541spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84979950303&doi=10.1534%2fgenetics.115.183285&partnerID=40&md5=24ce4fe8ad1bdc36b9c88f870227f3c7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acid substitutionspa
dc.subject.keywordinsecteng
dc.subject.keywordgeneticeng
dc.subject.keywordgeneticeng
dc.subject.keywordgeneticeng
dc.subject.keywordArticlespa
dc.subject.keywordBackground selectionspa
dc.subject.keywordButterflyspa
dc.subject.keywordChromosome sizespa
dc.subject.keywordCodon usagespa
dc.subject.keywordDna base compositionspa
dc.subject.keywordEffective population sizespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGenotypespa
dc.subject.keywordHeliconius melpomenespa
dc.subject.keywordHeterozygosityspa
dc.subject.keywordNatural selectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPopulation differentiationspa
dc.subject.keywordPopulation structurespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSelective sweepspa
dc.subject.keywordSpontaneous mutationspa
dc.subject.keywordAnimalspa
dc.subject.keywordButterflyspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic recombinationspa
dc.subject.keywordGenetic selectionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordInsect chromosomespa
dc.subject.keywordAmino acid substitutionspa
dc.subject.keywordAnimalsspa
dc.subject.keywordButterfliesspa
dc.subject.keywordChromosomeseng
dc.subject.keywordPolymorphismeng
dc.subject.keywordRecombinationeng
dc.subject.keywordSelectioneng
dc.subject.keywordBackground selectionspa
dc.subject.keywordEffective population sizespa
dc.subject.keywordGenetic hitchhikingspa
dc.subject.keywordRecombination ratespa
dc.subject.keywordSelective sweepsspa
dc.titleNatural selection and genetic diversity in the butterfly heliconius melpomenespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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