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Fungal biomarkers in HIV-associated disseminated histoplasmosis

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dc.creatorAdenis, Antoinespa
dc.creatorLortholary, Olivierspa
dc.creatorNacher, Mathieuspa
dc.creatorGomez, Beatriz L.Beatriz L.spa
dc.creatorCaceres Contreras, Diego Hernandospa
dc.creatorChiller, Tomspa
dc.creatorVreden, Stephenspa
dc.creatorVan Eer, Marjaspa
dc.creatorBougnoux, Marie Elisabethspa
dc.creatorMac Donald, Sigridspa
dc.creatorMoussiegt, Aurorespa
dc.date.accessioned2025-07-21T16:43:58Z
dc.date.available2025-07-21T16:43:58Z
dc.date.created2025-04-01spa
dc.date.issued2025-04-01spa
dc.description.abstractObjectives: Diagnosis of HIV-associated histoplasmosis remains challenging. Our objective was to compare the performances of (1?3)-?-D-Glucan (BDG) and aspergillus galactomannan (GM) antigen for the diagnosis of HIV-associated histoplasmosis. Methods: We performed a diagnostic accuracy study using frozen primary serum specimens issued from consecutive hospitalized people living with HIV (PLWH) and blindly tested for BDG and GM using FungitellR and PlateliaTM Aspergillus, respectively. Results: We included 121 sera with 92 HIV-associated histoplasmosis cases and 29 negative controls. At thresholds of 150 pg/ml and 0.5 for BDG and GM, the sensitivity and specificity were 95% (85-100) vs 90% (77-100) and 52% (34-70) vs 83% (69-97), respectively. The receiver operating characteristics (ROC) curves showed area under the curves of 0.82 (0.68-0.91) vs 0.92 (0.80-0.98) for BDG and GM, respectively. Post-test probabilities showed best performances at lowest thresholds for a negative testing of BDG and GM and at the 0.7 threshold for a positive GM test. Conclusions: If BDG alone may rule out histoplasmosis when negative, GM alone, either positive or negative, showed the best performances for the diagnosis of histoplasmosis. Given the poorer performances of BDG and GM than Histoplasma antigen detection assays commercially available, they should be considered as an alternative in settings where Histoplasma antigen detection assays remain unavailable. However, this study essentially provides insights in the performances of fungal biomarkers in disseminated histoplasmosis and does not represent recommendations for best practices.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2024.107360spa
dc.identifier.issn1201-9712spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46073
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.ispartofInternational Journal of Infectious Diseases Volume 153, April 2025, 107360spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1201971224004351spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceInternational Journal of Infectious Diseasesspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMicrobiologíaeng
dc.subject.keywordHIVeng
dc.subject.keywordHistoplasmosiseng
dc.subject.keywordGlucaneng
dc.subject.keywordGalactomannaneng
dc.subject.keywordDiagnostic performanceseng
dc.titleFungal biomarkers in HIV-associated disseminated histoplasmosisspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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