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Supervivencia de pacientes cirróticos en lista de espera con infecciones bacterianas atendidos en un centro de referencia

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dc.contributor.advisorBeltrán Galvis, Óscar Alfredo
dc.contributor.advisorBarragán González, Ana María
dc.creatorRamírez Daza, David José
dc.creator.degreeEspecialista en Gastroenterología
dc.creator.degreeLevelMaestría
dc.date.accessioned2026-01-22T16:50:46Z
dc.date.available2026-01-22T16:50:46Z
dc.date.created2026-01-18
dc.descriptionIntroducción: Las infecciones por gérmenes multirresistentes (MDR) incrementan la morbimortalidad en pacientes cirróticos en lista de espera para trasplante. Objetivo: Describir la probabilidad de supervivencia de pacientes cirróticos con infecciones bacterianas resistentes en un centro de referencia. Metodología: Cohorte descriptiva de pacientes hospitalizados. Se emplearon curvas de Kaplan-Meier para analizar mortalidad, ingreso a UCI y trasplante. Resultados: En 129 pacientes (156 eventos), con predominio de etiología autoinmune (42,6%), prevalecieron infecciones nosocomiales (50,3%) y bacteriemias (49%), principalmente por bacilos Gram negativos. La descripción de supervivencia confirmó un peor pronóstico a largo plazo para el grupo MDR. El hallazgo crítico fue la diferencia en el riesgo acumulado de ingreso a UCI: 0,55 en el grupo MDR versus 0,20 en el grupo sin MDR. Conclusión: La infección por MDR en pacientes pre-trasplante disminuye la supervivencia sostenida comparado con infecciones no resistentes y se asocia a un riesgo mayor de requerir cuidados intensivos.
dc.description.abstractIntroduction: Multidrug-resistant (MDR) infections increase morbidity and mortality in cirrhotic patients on the transplant waiting list. Objective: To describe the survival probability of cirrhotic patients with resistant bacterial infections at a referral center. Methodology: Descriptive cohort of hospitalized patients. Kaplan-Meier curves were used to analyze mortality, ICU admission, and transplantation. Results: In 129 patients (156 events), with a predominance of autoimmune etiology (42.6%), nosocomial infections (50.3%) and bacteremias (49%) prevailed, mainly due to Gram- negative bacilli. Survival description confirmed a worse long-term prognosis for the MDR group. The critical finding was the difference in the cumulative risk of ICU admission: 0.55 in the MDR group versus 0.20 in the non-MDR group.
dc.format.extent69 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_47272
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/47272
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Gastroenterología
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dc.rights.accesoAbierto (Texto Completo)
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCirrosis
dc.subjectInfecciones
dc.subjectBacterias
dc.subjectTrasplante
dc.subject.keywordCirrhosis
dc.subject.keywordInfections
dc.subject.keywordBacteria
dc.subject.keywordTransplantation
dc.subject.keywordSurvival
dc.titleSupervivencia de pacientes cirróticos en lista de espera con infecciones bacterianas atendidos en un centro de referencia
dc.title.TranslatedTitleSurvival of cirrhotic patients on waiting list with bacterial infections treated at a referral center
dc.title.alternativeSupervivencia de pacientes cirróticos en lista de espera con infecciones bacterianas
dc.typemasterThesis
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de grado
local.department.reportEscuela de Medicina y Ciencias de la Salud
local.regionesBogotá
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