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Evaluation of the multispecies coalescent method to explore intra-Trypanosoma cruzi i relationships and genetic diversity

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dc.creatorGómez-Hernández C.spa
dc.creatorPérez S.D.spa
dc.creatorRezende-Oliveira K.spa
dc.creatorBarbosa C.G.spa
dc.creatorLages-Silva E.spa
dc.creatorRamírez L.E.spa
dc.creatorRamírez, Juan Davidspa
dc.date.accessioned2020-05-25T23:57:53Z
dc.date.available2020-05-25T23:57:53Z
dc.date.created2019spa
dc.description.abstractChagas Disease is a zoonosis caused by the parasite Trypanosoma cruzi. Several high-resolution markers have subdivided T. cruzi taxon into at least seven lineages or Discrete Typing Units (DTUs) (TcI-TcVI and TcBat). Trypanosoma cruzi I is the most diverse and geographically widespread DTU. Recently a TcI genotype related to domestic cycles was proposed and named as TcIDOM. Herein, we combined traditional markers and housekeeping genes and applied a Multispecies Coalescent method to explore intra-TcI relationships, lineage boundaries and genetic diversity in a random set of isolates and DNA sequences retrieved from Genbank from different countries in the Americas. We found further evidence supporting TcIDOM as an independent and emerging genotype of TcI at least in Colombia and Venezuela. We also found evidence of high phylogenetic incongruence between parasite's gene trees (including introgression) and embedded species trees, and a lack of genetic structure among geography and hosts, illustrating the complex dynamics and epidemiology of TcI across the Americas. These findings provide novel insights into T. cruzi systematics and epidemiology and support the need to assess parasite diversity and lineage boundaries through hypothesis testing using different approaches to those traditionally employed, including the Bayesian Multispecies coalescent method. Copyright © Cambridge University Press 2019.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1017/S0031182019000428
dc.identifier.issn14698161
dc.identifier.issn00311820
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22761
dc.language.isoengspa
dc.publisherCambridge University Pressspa
dc.relation.citationEndPage1074
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage1063
dc.relation.citationTitleParasitology
dc.relation.citationVolumeVol. 146
dc.relation.ispartofParasitology, ISSN:14698161, 00311820, Vol.146, No.8 (2019); pp. 1063-1074spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065547318&doi=10.1017%2fS0031182019000428&partnerID=40&md5=2ed77c39877947bdf373245913299873spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGenomic DNAspa
dc.subject.keywordMolecular markerspa
dc.subject.keywordArticlespa
dc.subject.keywordChagas diseasespa
dc.subject.keywordCladisticsspa
dc.subject.keywordGene structurespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHousekeeping genespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasite cultivationspa
dc.subject.keywordParasite isolationspa
dc.subject.keywordPriority journalspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordChagas diseasespa
dc.subject.keywordDiscrete typing unitspa
dc.subject.keywordGenotypespa
dc.subject.keywordHousekeeping genesspa
dc.subject.keywordLineagespa
dc.subject.keywordMultispecies coalescentspa
dc.titleEvaluation of the multispecies coalescent method to explore intra-Trypanosoma cruzi i relationships and genetic diversityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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