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Zika virus and autoimmunity. One-step forward

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dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Y.spa
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRodríguez Velandia, Yhojan Alexisspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:00:45Z
dc.date.available2020-05-26T00:00:45Z
dc.date.created2017spa
dc.description.abstractZika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2017.10.008
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23267
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage1245
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage1237
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 16
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.16, No.12 (2017); pp. 1237-1245spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85032192996&doi=10.1016%2fj.autrev.2017.10.008&partnerID=40&md5=3b5c4c38725e44754309514ad15bca1fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordthrombocytopeniceng
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordidiopathiceng
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCase control studyspa
dc.subject.keywordClinical articlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordData extractionspa
dc.subject.keywordFemalespa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHumanspa
dc.subject.keywordIdiopathic thrombocytopenic purpuraspa
dc.subject.keywordImmunomodulationspa
dc.subject.keywordInformation processingspa
dc.subject.keywordMalespa
dc.subject.keywordMedical literaturespa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordNervous system electrophysiologyspa
dc.subject.keywordPhenotypespa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatic diseasespa
dc.subject.keywordThyroid diseasespa
dc.subject.keywordZika feverspa
dc.subject.keywordZika virusspa
dc.subject.keywordComplicationspa
dc.subject.keywordImmunologyspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGuillain-barre syndromespa
dc.subject.keywordHumansspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordPurpuraeng
dc.subject.keywordZika virus infectionspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGuillain-barré syndromespa
dc.subject.keywordIdiopathic thrombocytopenic purpuraspa
dc.subject.keywordThrombocytopeniaspa
dc.subject.keywordZika virusspa
dc.titleZika virus and autoimmunity. One-step forwardspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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