Ítem
Acceso Abierto

Nucleotide excision repair in chronic neurodegenerative diseases

Mostrar el registro sencillo de la publicación
dc.creatorSepe, Saraspa
dc.creatorPayan-Gomez, Cesarspa
dc.creatorMilanese, Chiaraspa
dc.creatorHoeijmakers, Jan H.spa
dc.creatorMastroberardino, Pier G.spa
dc.date.accessioned2020-05-26T00:06:11Z
dc.date.available2020-05-26T00:06:11Z
dc.date.created2013spa
dc.description.abstractImpaired DNA repair involving the nucleotide excision repair (NER)/transcription-coupled repair (TCR) pathway cause human pathologies associated with severe neurological symptoms. These clinical observations suggest that defective NER/TCR might also play a critical role in chronic neurodegenerative disorders (ND), such as Alzheimer's and Parkinson's disease. Involvement of NER/TCR in these disorders is also substantiated by the evidence that aging constitutes the principal risk factor for chronic ND and that this DNA repair mechanism is very relevant for the aging process itself. Our understanding of the exact role of NER/TCR in chronic ND, however, is extremely rudimentary; while there is no doubt that defective NER/TCR can lead to neuronal death, evidence for its participation in the etiopathogenesis of ND is inconclusive thus far. Here we summarize the experimental observations supporting a role for NER/TCR in chronic ND and suggest questions and lines of investigation that might help in addressing this important issue. We also present a preliminary yet unprecedented meta-analysis on human brain microarray data to understand the expression levels of the various NER factors in the anatomical areas relevant for chronic ND pathogenesis. In summary, this review intends to highlight elements supporting a role of NER/TCR in these devastating disorders and to propose potential strategies of investigation. © 2013 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.dnarep.2013.04.009
dc.identifier.issn15687864
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23865
dc.language.isoengspa
dc.relation.citationEndPage577
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage568
dc.relation.citationTitleDNA Repair
dc.relation.citationVolumeVol. 12
dc.relation.ispartofDNA Repair, ISSN:15687864, Vol.12, No.8 (2013); pp. 568-577spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84880637848&doi=10.1016%2fj.dnarep.2013.04.009&partnerID=40&md5=b405bf7f45249c999b15047d8db701a2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAgingspa
dc.subject.keywordanimaleng
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordAnatomical variationspa
dc.subject.keywordArticlespa
dc.subject.keywordChronic diseasespa
dc.subject.keywordDegenerative diseasespa
dc.subject.keywordDna repairspa
dc.subject.keywordExcision repairspa
dc.subject.keywordGene expressionspa
dc.subject.keywordHumanspa
dc.subject.keywordMicroarray analysisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordObservational studyspa
dc.subject.keywordParkinson diseasespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordAlzheimer's diseasespa
dc.subject.keywordDna damagespa
dc.subject.keywordHuntington's diseasespa
dc.subject.keywordNeurodegenerationspa
dc.subject.keywordParkinson's diseasespa
dc.subject.keywordTranscriptomicsspa
dc.subject.keywordAgingspa
dc.subject.keywordAnimalsspa
dc.subject.keywordBrainspa
dc.subject.keywordChronic diseasespa
dc.subject.keywordDisease modelseng
dc.subject.keywordDna damagespa
dc.subject.keywordDna repairspa
dc.subject.keywordHumansspa
dc.subject.keywordNeurodegenerative diseasesspa
dc.subject.keywordNeuronsspa
dc.subject.keywordAlzheimer's diseasespa
dc.subject.keywordDna damagespa
dc.subject.keywordHuntington's diseasespa
dc.subject.keywordNeurodegenerationspa
dc.subject.keywordParkinson's diseasespa
dc.subject.keywordTranscriptomicsspa
dc.titleNucleotide excision repair in chronic neurodegenerative diseasesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Nucleotide_excision_repair_in_chronic_neurodegenerative_diseases.pdf
Tamaño:
1.6 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos