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Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine

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dc.creatorPatarroyo, Manuel Espa
dc.creatorBermudez, Adriana
dc.creatorMoreno-Vranich, Armandospa
dc.date.accessioned2020-05-26T00:08:01Z
dc.date.available2020-05-26T00:08:01Z
dc.date.created2012spa
dc.description.abstractIf ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1586/erv.12.57
dc.identifier.issn14760584
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24048
dc.language.isoengspa
dc.relation.citationEndPage1070
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage1057
dc.relation.citationTitleExpert Review of Vaccines
dc.relation.citationVolumeVol. 11
dc.relation.ispartofExpert Review of Vaccines, ISSN:14760584, Vol.11, No.9 (2012); pp. 1057-1070spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84869383556&doi=10.1586%2ferv.12.57&partnerID=40&md5=eadac6479acc1a8c5b2d941bfa32df38spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApical merozoite antigen 1spa
dc.subject.keywordsubuniteng
dc.subject.keywordErythrocyte membrane protein 1spa
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMerozoite surface proteinspa
dc.subject.keywordParasite antigenspa
dc.subject.keywordRhoptry associated proteinspa
dc.subject.keywordSerine repeat antigen 5spa
dc.subject.keywordSporozoite proteinspa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug synthesisspa
dc.subject.keywordDrug targetingspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordMerozoitespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium knowlesispa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordReviewspa
dc.subject.keywordSporozoitespa
dc.subject.keywordDrug discoveryspa
dc.subject.keywordHumansspa
dc.subject.keywordMagnetic resonance spectroscopyspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein conformationspa
dc.subject.keywordVaccineseng
dc.subject.keywordFully protectivespa
dc.subject.keywordSubunit-basedspa
dc.subject.keywordSynthetic antimalaria vaccinespa
dc.titleTowards the development of a fully protective Plasmodium falciparum antimalarial vaccinespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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