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Prevalence and impact of respiratory symptoms in a population of patients with COPD in Latin America: The LASSYC observational study

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dc.creatorMiravitlles, Marcspa
dc.creatorMenezes, Anaspa
dc.creatorVarela, Maria Victorina Lópezspa
dc.creatorCasas, Alejandrospa
dc.creatorUgalde, Luisspa
dc.creatorRamirez-Venegas, Alejandraspa
dc.creatorMendoza, Lauraspa
dc.creatorLópez, Anaspa
dc.creatorWehrmeister, Fernando C.spa
dc.creatorSurmont, Filipspa
dc.creatorde Oca, Maria Montesspa
dc.date.accessioned2020-05-25T23:58:47Z
dc.date.available2020-05-25T23:58:47Z
dc.date.created2018spa
dc.description.abstractBackground To analyse the relationship between symptoms at different times during the 24-hour day and outcomes in COPD. Methods Observational cross-sectional study in a patients from 7 Latin American countries. The frequency of symptoms in the morning, at night and during the day was explored by means of standardised and validated questionnaires, and the relationship between symptoms and exacerbations and quality of life were investigated. Results 734 patients (59.6% male, mean age 69.5 years, mean FEV1 50% predicted normal) were recruited. The most frequent symptoms during the day were dyspnea (75% of patients, of which 94% mild-moderate) and cough (72.2%, of which 93.4% mild-moderate). Highly symptomatic patients had a greater impairment in FEV1, more exacerbations and worse scores in COPD assessment test (CAT) and Body Mass Index, Obstruction, Dyspnoea and Exacerbations (BODEx) index (all p and lt; 0.001). Morning symptoms were more frequent than night-time symptoms, particularly cough and dyspnoea (morning: 50.1% and 45.7%; night-time: 33.2% and 24.4%, respectively), and mostly rated as mild or moderate. Patients with morning or night-time symptoms presented with worse severity of daytime symptoms. There was a strong correlation between intensity of daytime with morning or night-time symptoms, as well as with CAT score (r = 0.715; p and lt; 0.001), but a weak correlation with FEV1 (r = ?0.205; p and lt; 0.001). Conclusion Morning symptoms were more frequent than night-time symptoms, and having either morning and/or night-time symptoms was associated with worse severity of daytime symptoms. Increased symptoms were strongly associated with worse quality of life and more frequent exacerbations, but weakly associated with airflow limitation. Clinical trial registration NCT02789540. © 2017 Elsevier Ltdeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.rmed.2017.11.018
dc.identifier.issn9546111
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22929
dc.language.isoengspa
dc.publisherW.B. Saunders Ltdspa
dc.relation.citationEndPage69
dc.relation.citationStartPage62
dc.relation.citationTitleRespiratory Medicine
dc.relation.citationVolumeVol. 134
dc.relation.ispartofRespiratory Medicine, ISSN:9546111, Vol.134,(2018); pp. 62-69spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85036649638&doi=10.1016%2fj.rmed.2017.11.018&partnerID=40&md5=2430e794b6273d593d85a12a7d8e918fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordBody massspa
dc.subject.keywordBody mass index obstruction dyspnoea and exacerbationsspa
dc.subject.keywordChronic obstructive lung diseasespa
dc.subject.keywordChronic obstructive lung disease assessement testspa
dc.subject.keywordCoughingspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease exacerbationspa
dc.subject.keywordDisease severityspa
dc.subject.keywordDyspneaspa
dc.subject.keywordFemalespa
dc.subject.keywordForced expiratory volumespa
dc.subject.keywordHumanspa
dc.subject.keywordLung functionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMulticenter studyspa
dc.subject.keywordNightspa
dc.subject.keywordObservational studyspa
dc.subject.keywordObstructionspa
dc.subject.keywordPatient-reported outcomespa
dc.subject.keywordPhysical activityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordQuality of lifespa
dc.subject.keywordRespiratory tract diseasespa
dc.subject.keywordRespiratory tract disease assessmentspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordSymptomspa
dc.subject.keywordThorax diseasespa
dc.subject.keywordAgespa
dc.subject.keywordChronic obstructive lung diseasespa
dc.subject.keywordCircadian rhythmspa
dc.subject.keywordClinical trialspa
dc.subject.keywordComplicationspa
dc.subject.keywordCoughingspa
dc.subject.keywordDyspneaspa
dc.subject.keywordExercisespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordAge factorsspa
dc.subject.keywordAgedspa
dc.subject.keywordCircadian rhythmspa
dc.subject.keywordCoughspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordDyspneaspa
dc.subject.keywordExercisespa
dc.subject.keywordFemalespa
dc.subject.keywordForced expiratory volumespa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPulmonary diseaseeng
dc.subject.keywordQuality of lifespa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordExacerbationsspa
dc.subject.keywordLatin americaspa
dc.subject.keywordQuality of lifespa
dc.subject.keywordSymptomsspa
dc.titlePrevalence and impact of respiratory symptoms in a population of patients with COPD in Latin America: The LASSYC observational studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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