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Infectious antibodies in systemic lupus erythematosus patients

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dc.creatorBerkun, Y.spa
dc.creatorZandman-Goddard, G.spa
dc.creatorBarzilai, O.spa
dc.creatorBoaz, M.spa
dc.creatorSherer, Y.spa
dc.creatorLarida, B.spa
dc.creatorBlank, M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorShoenfeld, Y.spa
dc.date.accessioned2020-08-06T16:20:30Z
dc.date.available2020-08-06T16:20:30Z
dc.date.created2009-10-30spa
dc.description.abstractInfections can act as environmental triggers that induce or promote systemic lupus erythematosus (SLE) in genetically predisposed individuals. New technologies, developed recently, enable simultaneous assessment of multiple antibodies. Antibodies to specific infectious agents may shed light into the mechanisms of induction of SLE. The aim of this study was to investigate the prevalence of seropositivity and the titers of antibodies to bacterial, viral, and parasitic agents in SLE patients compared with non-autoimmune controls. Sera from 260 individuals (120 SLE patients and 140 controls) were tested by the BioPlex 2200 Multiplexed Immunoassay method (BioRad) for the prevalence and titers of antibodies to eight infectious agents (Epstein—Barr virus: early antigen IgG, nuclear antigen IgG, viral capsid antigen IgG and IgM, heterophile IgM; cytomegalovirus IgG and IgM; Toxoplasma gondii IgG and IgM; rubella IgG and IgM; Treponema pallidum TPr15G, TPr17G, TPr47G; herpes simplex virus type 1 and 2 IgG; hepatitis C virus and hepatitis B core antibodies. Cytomegalovirus IgM and Epstein—Barr virus early antigen IgG (but not other Epstein—Barr virus antigens) were significantly more prevalent in SLE patients than in controls. Conversely, positive titers of hepatitis B core and rubella IgG antibodies were less prevalent in the SLE patients than in controls. Other differences in titer positivity prevalence were not detected between patients and controls. The titers of the cytomegalovirus IgM, Toxoplasma IgG, Epstein—Barr virus early antigen, and viral capsid antigen IgG antibodies were significantly higher in SLE compared with controls. Our data suggest the importance of previous exposure to infectious agents in the induction and the prevention of SLE. Lupus (2009) 18, 1129—1135.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1177/0961203309345729
dc.identifier.issnISSN: 0961-2033
dc.identifier.issnEISSN: 1477-0962
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26035
dc.language.isoengspa
dc.publisherSage Publishingspa
dc.relation.citationEndPage1135
dc.relation.citationIssueNo. 13
dc.relation.citationStartPage1129
dc.relation.citationTitleLupus
dc.relation.citationVolumeVol. 18
dc.relation.ispartofLupus, ISSN: 0961-2033 ; EISSN: 1477-0962, Vol.18, No.13 (2009); pp.1129-1135spa
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/0961203309345729spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceLupusspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordInfectionsspa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordRubellaspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordEpstein Barr virusspa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordHepatitis Cspa
dc.subject.keywordHerpes simplexspa
dc.subject.keywordTreponema pallidumspa
dc.subject.keywordAntibodiesspa
dc.subject.keywordSLEspa
dc.titleInfectious antibodies in systemic lupus erythematosus patientsspa
dc.title.TranslatedTitleAnticuerpos infecciosos en pacientes con lupus eritematoso sistémicospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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