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New role of free radicals in exercise: Another paradox?

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dc.creatorUrbina Bonilla, Adriana del Pilarspa
dc.date.accessioned2020-05-26T00:04:51Z
dc.date.available2020-05-26T00:04:51Z
dc.date.created2008spa
dc.description.abstractIntroduction: Physical activity conduces to oxidative stress, which produces undesirable effects. However, it is well known that free radicals, when present in low concentrations, also have physiological effects in the exercise adaptation process. In addition, the majority of antioxidant supplementation studies, in spite of the fact of decreases oxidative stress, have failed to show a performance improving. Objectives: The goals of this review are to reinterpret the available evidence about the role of free radicals in exercise, and to analyze why antioxidant supplementation have not shown the expectable ergogenic effect. Methods: The following topics were reviewed: i) the free radical biology; ii) antioxidant systems; iii) exercise induced-oxidative stress; iv) oxidative stress and physical performance; and v) antioxidant supplementation and physical performance. Results: There is evidence that physical exercise is associated with excessive free radical production. Deleterious effects of free radicals in physical performance have been shown by in situ studies, although evidence in humans is also available. Physical exercise results in muscular hypoxia, which conduces to adaptative responses, probably through free radical-mediated HIF-1? stabilization. Moreover, a certain level of free radicals is necessary for optimal muscle contractility. Conclusions: Free radicals are necessary for exercise-induced hypoxia adaptation and muscle contraction, for that reason long term antioxidant supplementation interfere with its physiological role. This, explain why antioxidants decrease oxidative stress markers but fail to improve physical performance. © 2008 Corporación Editora Médica del Valle.spa
dc.format.mimetypeapplication/pdf
dc.identifier.issn16579534
dc.identifier.issn01208322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23725
dc.language.isospaspa
dc.relation.citationEndPage275
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage266
dc.relation.citationTitleColombia Medica
dc.relation.citationVolumeVol. 39
dc.relation.ispartofColombia Medica, ISSN:16579534, 01208322, Vol.39, No.3 (2008); pp. 266-275spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-54749128946&partnerID=40&md5=2ecf3e9056db36f196d44a232368d2a9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntioxidantspa
dc.subject.keywordFree radicalspa
dc.subject.keywordHypoxia inducible factor 1alphaspa
dc.subject.keywordDiet supplementationspa
dc.subject.keywordEvidence based medicinespa
dc.subject.keywordExercisespa
dc.subject.keywordExercise physiologyspa
dc.subject.keywordHumanspa
dc.subject.keywordHypoxemiaspa
dc.subject.keywordMuscle contractilityspa
dc.subject.keywordMuscle contractionspa
dc.subject.keywordOxidative stressspa
dc.subject.keywordPhysical activityspa
dc.subject.keywordPhysical performancespa
dc.subject.keywordProtein stabilityspa
dc.subject.keywordReviewspa
dc.subject.keywordAntioxidantsspa
dc.subject.keywordExercisespa
dc.subject.keywordFree radicalsspa
dc.subject.keywordHypoxiaspa
dc.subject.keywordOxidative stressspa
dc.subject.keywordTrainingspa
dc.titleNew role of free radicals in exercise: Another paradox?spa
dc.title.TranslatedTitleNuevo papel de los radicales libres de oxígeno en el ejercicio: ¿Otra paradoja?por
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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