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Severe acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia: Case reports

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dc.creatorCortés, Diana Alejandraspa
dc.creatorAguilar, María Camilaspa
dc.creatorRíos, Hernán Andresspa
dc.creatorRodríguez, Francisco Joséspa
dc.creatorMontes, Kelly Verónicaspa
dc.creatorMarín, Jorge Enrique Gómez-spa
dc.creatorde-la-Torre, Alejandraspa
dc.date.accessioned2020-05-26T00:09:43Z
dc.date.available2020-05-26T00:09:43Z
dc.date.created2020spa
dc.description.abstractPropose: To report two cases of severe acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia. Observations: We report two immunocompetent male patients aged 44- and 67-years-old who, despite not having visited the Amazonian region in Colombia, had severe bilateral posterior uveitis and extensive-bilateral macular lesions and multiple organ failure that required admission to an intensive care unit. Toxoplasma gondii was positive by PCR assay in vitreous humor samples. Patients were treated with intravitreal clindamycin and dexamethasone in addition to systemic treatment with trimethoprim-sulfamethoxazole. In both patients, infection by atypical strains was confirmed; in one case by serotyping and in another one by genotyping (ROP 18 virulent allele). After 2 and 4 months of treatment respectively, the patients showed improvement of the posterior uveitis and its systemic manifestations. However, there was no significant visual acuity improvement due to bilateral extensive macular involvement. Conclusions and importance: Clinicians should be aware that toxoplasmosis originating from South America could be associated with severe acute multisystemic and intraocular bilateral involvement, even in patients with no history of exposure to jungle environments. © 2020eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ajoc.2020.100661
dc.identifier.issn24519936
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24174
dc.language.isoengspa
dc.publisherElsevier Incspa
dc.relation.citationTitleAmerican Journal of Ophthalmology Case Reports
dc.relation.citationVolumeVol. 18
dc.relation.ispartofAmerican Journal of Ophthalmology Case Reports, ISSN:24519936, Vol.18,(2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081697696&doi=10.1016%2fj.ajoc.2020.100661&partnerID=40&md5=eb2b13c11f1a4e3c090ee21b80bb8341spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordClindamycinspa
dc.subject.keywordCotrimoxazolespa
dc.subject.keywordDexamethasonespa
dc.subject.keywordValaciclovirspa
dc.subject.keywordVancomycinspa
dc.subject.keywordAdd on therapyspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelespa
dc.subject.keywordAnamnesisspa
dc.subject.keywordAntiviral therapyspa
dc.subject.keywordArticlespa
dc.subject.keywordBacterial endophthalmitisspa
dc.subject.keywordBacterial infectionspa
dc.subject.keywordBest corrected visual acuityspa
dc.subject.keywordBiomicroscopyspa
dc.subject.keywordCase reportspa
dc.subject.keywordChorioretinopathyspa
dc.subject.keywordClinical articlespa
dc.subject.keywordColombiaspa
dc.subject.keywordConjunctival hyperemiaspa
dc.subject.keywordDisease severityspa
dc.subject.keywordEndophthalmitisspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordEpstein barr virus infectionspa
dc.subject.keywordEye examinationspa
dc.subject.keywordFollow upspa
dc.subject.keywordGenotyping techniquespa
dc.subject.keywordHospitalizationspa
dc.subject.keywordHumanspa
dc.subject.keywordHypertensionspa
dc.subject.keywordImmunocompromised patientspa
dc.subject.keywordIntensive care unitspa
dc.subject.keywordLaboratory testspa
dc.subject.keywordMalespa
dc.subject.keywordMedical historyspa
dc.subject.keywordMolecular phylogenyspa
dc.subject.keywordMultiple organ failurespa
dc.subject.keywordMyocarditisspa
dc.subject.keywordMyositisspa
dc.subject.keywordNephritisspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordOptical coherence tomographyspa
dc.subject.keywordPericarditisspa
dc.subject.keywordPneumoniaspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPolymyositisspa
dc.subject.keywordPolyneuropathyspa
dc.subject.keywordPyrexia idiopathicaspa
dc.subject.keywordRespiratory failurespa
dc.subject.keywordRetina detachmentspa
dc.subject.keywordSerologyspa
dc.subject.keywordSerotypingspa
dc.subject.keywordSystemic therapyspa
dc.subject.keywordThrombocytopeniaspa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordTreatment durationspa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordUrban areaspa
dc.subject.keywordUveitisspa
dc.subject.keywordVisual acuityspa
dc.subject.keywordVitreous bodyspa
dc.subject.keywordVitreous opacityspa
dc.subject.keywordVitritisspa
dc.subject.keywordAtypical strainsspa
dc.subject.keywordMultiple organ failurespa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordRop18spa
dc.subject.keywordToxoplasma gondiispa
dc.titleSevere acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia: Case reportsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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