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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

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dc.creatorLessard, Christopher Jspa
dc.creatorLi, Hespa
dc.creatorAdrianto, Indraspa
dc.creatorIce, John Aspa
dc.creatorRasmussen, Astridspa
dc.creatorGrundahl, Kiely Mspa
dc.creatorKelly, Jennifer Aspa
dc.creatorDozmorov, Mikhail Gspa
dc.creatorMiceli-Richard, Corinnespa
dc.creatorBowman, Simonspa
dc.creatorLester, Suespa
dc.creatorEriksson, Perspa
dc.creatorEloranta, Maija-Leenaspa
dc.creatorBrun, Johan Gspa
dc.creatorGøransson, Lasse Gspa
dc.creatorHarboe, Ernaspa
dc.creatorGuthridge, Joel Mspa
dc.creatorKaufman, Kenneth Mspa
dc.creatorKvarnström, Marikaspa
dc.creatorJazebi, Helmispa
dc.creatorGraham, Deborah S Cunninghamespa
dc.creatorGrandits, Martha Espa
dc.creatorNazmul-Hossain, Abu N Mspa
dc.creatorPatel, Ketanspa
dc.creatorAdler, Adam Jspa
dc.creatorMaier-Moore, Jacen Sspa
dc.creatorFarris, A Darisespa
dc.creatorBrennan, Michael Tspa
dc.creatorLessard, James Aspa
dc.creatorChodosh, Jamesspa
dc.creatorGopalakrishnan, Rajaramspa
dc.creatorHefner, Kimberly Sspa
dc.creatorHouston, Glen Dspa
dc.creatorHuang, Andrew J Wspa
dc.creatorHughes, Pamela Jspa
dc.creatorLewis, David Mspa
dc.creatorRadfar, Lidaspa
dc.creatorRohrer, Michael Dspa
dc.creatorStone, Donald Uspa
dc.creatorWren, Jonathan Dspa
dc.creatorVyse, Timothy Jspa
dc.creatorGaffney, Patrick Mspa
dc.creatorJames, Judith Aspa
dc.creatorOmdal, Roaldspa
dc.creatorWahren-Herlenius, Mariespa
dc.creatorIllei, Gabor Gspa
dc.creatorWitte, Torstenspa
dc.creatorJonsson, Rolandspa
dc.creatorRischmueller, Maureenspa
dc.creatorRönnblom, Larsspa
dc.creatorNordmark, Gunnelspa
dc.creatorNg, Wan-Faispa
dc.creatorMariette, Xavierspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorRhodus, Nelson Lspa
dc.creatorSegal, Barbara Mspa
dc.creatorScofield, R Halspa
dc.creatorMontgomery, Courtney Gspa
dc.creatorHarley, John Bspa
dc.creatorSivils, Kathy Lspa
dc.date.accessioned2020-05-25T23:57:16Z
dc.date.available2020-05-25T23:57:16Z
dc.date.created2013spa
dc.description.abstractSjögren's syndrome is a common autoimmune disease (affecting ?0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (P meta = 7.65 × 10 -114), we establish associations with IRF5-TNPO3 (P meta = 2.73 × 10 -19), STAT4 (P meta = 6.80 × 10 -15), IL12A (P meta = 1.17 × 10 -10), FAM167A-BLK (P meta = 4.97 × 10 -10), DDX6-CXCR5 (P meta = 1.10 × 10 -8) and TNIP1 (P meta = 3.30 × 10 -8). We also observed suggestive associations (P meta less than 5 × 10 -5) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome. © 2013 Nature America, Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/ng.2792
dc.identifier.issn10614036
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22639
dc.language.isoengspa
dc.relation.citationEndPage1294
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage1284
dc.relation.citationTitleNature Genetics
dc.relation.citationVolumeVol. 45
dc.relation.ispartofNature Genetics, ISSN:10614036, Vol.45, No.11 (2013); pp. 1284-1294spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84887116043&doi=10.1038%2fng.2792&partnerID=40&md5=4353ef15129589ad1e39c3cb4a239f45spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordB lymphocyte induced maturation protein 1spa
dc.subject.keywordInnateeng
dc.subject.keywordChemokine receptor CXCR5spa
dc.subject.keywordHLA DQA1 antigenspa
dc.subject.keywordHLA DQB1 antigenspa
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordInterferon regulatory factor 5spa
dc.subject.keywordInterleukin 12p35spa
dc.subject.keywordSecurinspa
dc.subject.keywordSTAT4 proteinspa
dc.subject.keywordAdaptive immunityspa
dc.subject.keywordArticlespa
dc.subject.keywordCase control studyspa
dc.subject.keywordChromatin immunoprecipitationspa
dc.subject.keywordChromosome 8spa
dc.subject.keywordControlled studyspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene locusspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHLA systemspa
dc.subject.keywordHumanspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordIntronspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMeta analysis (topic)spa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordAdaptive Immunityspa
dc.subject.keywordGenetic Association Studiesspa
dc.subject.keywordGenetic Locispa
dc.subject.keywordGenetic Variationspa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordSjogren's Syndromespa
dc.titleVariants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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