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TNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombians

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dc.creatorGomez L.M.spa
dc.creatorRuiz-Narváez E.A.spa
dc.creatorPineda-Tamayo R.spa
dc.creatorRojas-Villarraga A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:15Z
dc.date.available2020-05-26T00:04:15Z
dc.date.created2007spa
dc.description.abstractObjective: To examine the contribution of tumor necrosis factor alpha (TNF) microsatellite (a to e) polymorphism to the genetic risk of developing rheumatoid arthritis (RA) in a northwestern Colombian population. Methods: This was an association study in which 108 RA patients and 222 matched individuals were enrolled. HLA-DRB1 and DQB1 polymorphisms were evaluated to examine for linkage disequilibrium between these loci and TNF microsatellites. Genotyping was performed using denaturing polyacrylamide gels and polymerase chain reaction-sequence techniques. Results: By unconditional logistic regression analysis, the TNFa6 allele (OR= 2.37, 95%CI 1.07-5.24) and the TNFb4 allele (OR= 3.01, 95%CI 1.07-9.00) were observed to be associated with disease. These associations were independent of HLA-DR and HLA-DQ since linkage disequilibrium between HLA class II and TNF microsatellites was not observed. In addition, patients with the TNFa8 allele had a five times greater risk of developing extra-articular manifestations as compared to patients without this allele (OR = 5.07, 95%CI 1.14-22.52), regardless of age and the duration of disease. Haplotype analysis disclosed a protective effect for TNFa7/b7/c1/d4/e3/-308G/-238G. Conclusion: These results confirm that the TNF locus exerts a primary influence on both susceptibility to and the severity of RA. © Copyright Clinical and Experimental Rheumatology 2007.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0392856X
dc.identifier.issn1593098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23670
dc.language.isoengspa
dc.relation.citationEndPage448
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage443
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 25
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN:0392856X, 1593098X, Vol.25, No.3 (2007); pp. 443-448spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34447626311&partnerID=40&md5=a15289a3721e07a0e85520acd2f6140fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCytokinespa
dc.subject.keywordrheumatoideng
dc.subject.keywordgeneticeng
dc.subject.keywordHla antigen class 2spa
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordTumor necrosis factor 238gspa
dc.subject.keywordTumor necrosis factor 308gspa
dc.subject.keywordTumor necrosis factor a6spa
dc.subject.keywordTumor necrosis factor a7spa
dc.subject.keywordTumor necrosis factor a8spa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordTumor necrosis factor b4spa
dc.subject.keywordTumor necrosis factor b7spa
dc.subject.keywordTumor necrosis factor c1spa
dc.subject.keywordTumor necrosis factor d4spa
dc.subject.keywordTumor necrosis factor e3spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdultspa
dc.subject.keywordAge distributionspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordClinical featurespa
dc.subject.keywordColombiaspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordDisease severityspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene linkage disequilibriumspa
dc.subject.keywordGene locusspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordLogistic regression analysisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein functionspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordAdultspa
dc.subject.keywordArthritiseng
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordLinkage disequilibriumspa
dc.subject.keywordMalespa
dc.subject.keywordMicrosatellite repeatsspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordRegression analysisspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordTumor necrosis factor-alphaspa
dc.subject.keywordGeneticspa
dc.subject.keywordHlaspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMicrosatellitesspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordTnfspa
dc.titleTNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombiansspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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