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High frequency of TDR in newly diagnosed human immunodeficiency virus type 1 (HIV-1) patients from Sao Paulo/Brazil

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dc.creatorPimentel,V. F.spa
dc.creatorAbecasis, A. Bspa
dc.creatorPortes, L.spa
dc.creatorPineda-Peña, Andrea C.spa
dc.creatorMatsuda, E. M.spa
dc.creatorGuimarães, P. M. S.spa
dc.creatorHársi, C. M.spa
dc.creatorDe Paula, J. L.spa
dc.creatorVandamme, A. M.spa
dc.creatorBrígido, F. M.spa
dc.date.accessioned2020-07-30T20:58:17Z
dc.date.available2020-07-30T20:58:17Z
dc.date.created2016-05spa
dc.description.abstractThe human immunodeficiency virus type 1 (HIV-1) epidemic in Sa˜o Paulo is dominated by subtypes B, F1 and C. The aim of this study was to characterize genotypes and transmitted drug resistance (TDR) among newly diagnosed HIV-1 individuals from January 2014 to February 2015 in Sa˜o Paulo. Population sequencing (PR þ RT) was performed on plasma viral RNA for 179 patients. For subtyping, we tested different automated tools-Rega v2.0, v.3.0, Blast Los Alamos, Scueal, Comet v1.0 and jpHMM-and performed phylogenetic analysis using the Neighbor-Joining method under K2-P model with MEGA and bootscanning using SimPlot. Sequences were submitted to the Stanford HIV Database CPR tool (http://cpr.stanford.edu/cpr.cgi) to investigate TDR. Statistical analysis was performed using GraphpadPrism software. Among the 179 sequences, the more prevalent subtypes were B (74%), C (12.3%), F (5.6%) and BF1 recombinants (5.6%). BC recombinants (1%) and subtypes D and G (<1%) were also found. In total, 28 patients (15.6%) with TDR were identified. 50% of these had TDR to NNRTIs, 40% to NRTIs and 14.2% to PIs. The frequency of TDR was significantly different between subtypes B, C and F1: 16% [Cl: 20.4–36.9], 0%[0-14.9] and 50% [23.7–76.3%], respectively (p< 0.0016). The HIV-1 epidemic in Sao Paulo is driven by subtype B, however – compared to previous studies - there is an increased prevalence of subtype C. The prevalence of TDR shows important differences between subtypes, with low prevalence of TDR in subtype C compared to significantly higher prevalence in subtypes B and F1eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/ve/vev024
dc.identifier.issnISSN: 2057-1577
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25621
dc.language.isoengspa
dc.publisherOxford University Pressspa
dc.relation.citationIssueNo. Supl. 1
dc.relation.citationStartPages8
dc.relation.citationTitleVirus Evolution
dc.relation.citationVolumeVol. 2
dc.relation.ispartofVirus Evolution, ISSN: 20571577, Vol.2, No.Supl. 1 (2016); pp. s8spa
dc.relation.ispartofInternational BioInformatics Workshop on Virus Evolution and Molecular Epidemiology, No. 20 (August 10-14, 2015); A23spa
dc.relation.urihttps://academic.oup.com/ve/article-pdf/2/suppl_1/S3/25026904/vev024.pdf#page=6spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto Referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordBiological Sciencesspa
dc.subject.keywordEvolutionary Biologyspa
dc.titleHigh frequency of TDR in newly diagnosed human immunodeficiency virus type 1 (HIV-1) patients from Sao Paulo/Brazilspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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