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Adiposity as a full mediator of the influence of cardiorespiratory fitness and inflammation in schoolchildren: The FUPRECOL Study

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dc.creatorGarcia-Hermoso A.spa
dc.creatorAgostinis-Sobrinho C.spa
dc.creatorMota J.spa
dc.creatorSantos R.M.spa
dc.creatorCorrea-Bautista J.E.spa
dc.creatorRamírez-Vélez R.spa
dc.date.accessioned2020-05-25T23:57:35Z
dc.date.available2020-05-25T23:57:35Z
dc.date.created2017spa
dc.description.abstractBackground and aims Studies in the paediatric population have shown inconsistent associations between cardiorespiratory fitness and inflammation independently of adiposity. The purpose of this study was (i) to analyse the combined association of cardiorespiratory fitness and adiposity with high-sensitivity C-reactive protein (hs-CRP), and (ii) to determine whether adiposity acts as a mediator on the association between cardiorespiratory fitness and hs-CRP in children and adolescents. Methods and results This cross-sectional study included 935 (54.7% girls) healthy children and adolescents from Bogotá, Colombia. The 20 m shuttle run test was used to estimate cardiorespiratory fitness. We assessed the following adiposity parameters: body mass index, waist circumference, and fat mass index and the sum of subscapular and triceps skinfold thickness. High sensitivity assays were used to obtain hs-CRP. Linear regression models were fitted for mediation analyses examined whether the association between cardiorespiratory fitness and hs-CRP was mediated by each of adiposity parameters according to Baron and Kenny procedures. Lower levels of hs-CRP were associated with the best schoolchildren profiles (high cardiorespiratory fitness + low adiposity) (p for trend and #x003C;0.001 in the four adiposity parameters), compared with unfit and overweight (low cardiorespiratory fitness + high adiposity) counterparts. Linear regression models suggest a full mediation of adiposity on the association between cardiorespiratory fitness and hs-CRP levels. Conclusions Our findings seem to emphasize the importance of obesity prevention in childhood, suggesting that having high levels of cardiorespiratory fitness may not counteract the negative consequences ascribed to adiposity on hs-CRP. © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II Universityeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.numecd.2017.04.005
dc.identifier.issn15903729
dc.identifier.issn09394753
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22701
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage533
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage525
dc.relation.citationTitleNutrition, Metabolism and Cardiovascular Diseases
dc.relation.citationVolumeVol. 27
dc.relation.ispartofNutrition, Metabolism and Cardiovascular Diseases, ISSN:15903729, 09394753, Vol.27, No.6 (2017); pp. 525-533spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018884477&doi=10.1016%2fj.numecd.2017.04.005&partnerID=40&md5=e9d525b295f2377d6387635331d9fc74spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordAutacoidspa
dc.subject.keywordBiological markerspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordAdolescentspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood analysisspa
dc.subject.keywordBody massspa
dc.subject.keywordCardiorespiratory fitnessspa
dc.subject.keywordChildspa
dc.subject.keywordChildhood obesityspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDietary intakespa
dc.subject.keywordDisease associationspa
dc.subject.keywordFat massspa
dc.subject.keywordFemalespa
dc.subject.keywordFood intakespa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSchool childspa
dc.subject.keywordSexual maturationspa
dc.subject.keywordSkinfold thicknessspa
dc.subject.keywordWaist circumferencespa
dc.subject.keywordAgespa
dc.subject.keywordBloodspa
dc.subject.keywordColombiaspa
dc.subject.keywordInflammationspa
dc.subject.keywordObesityspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPediatric Obesityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorspa
dc.subject.keywordStatistical modelspa
dc.subject.keywordAdiposityspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAge Factorsspa
dc.subject.keywordBiomarkersspa
dc.subject.keywordC-Reactive Proteinspa
dc.subject.keywordCardiorespiratory Fitnessspa
dc.subject.keywordChildspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-Sectional Studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInflammationspa
dc.subject.keywordInflammation Mediatorsspa
dc.subject.keywordLinear Modelsspa
dc.subject.keywordMalespa
dc.subject.keywordPediatric Obesityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordAerobic fitnessspa
dc.subject.keywordColombiaspa
dc.subject.keywordHigh-sensitivity C-reactive proteinspa
dc.subject.keywordYouth populationspa
dc.titleAdiposity as a full mediator of the influence of cardiorespiratory fitness and inflammation in schoolchildren: The FUPRECOL Studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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