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A comprehensive scoping review of methodological approaches and clinical applications of tear fluid biomarkers

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dc.creatorJoachim, Stephanie C.spa
dc.creatorMrugacz, Malgorzataspa
dc.creatorDutta, Debarunspa
dc.creatorLengyel, Imrespa
dc.creatorAsbell, Lennyspa
dc.creatorSabater, Alfonso L.spa
dc.creatorOjeda Pedraza, Diegospa
dc.creatorMagno, Morten s.spa
dc.creatorUtheim, Tor P.spa
dc.creatorSimsek, Emrullahspa
dc.creatorAlp Kilicaslan, Necatispa
dc.creatorOnal, Iremspa
dc.creatorMergen, Burakspa
dc.creatorHagan, Suzannespa
dc.creatorEnríquez-de-Salamanca, Amaliaspa
dc.creatorPot, Davyspa
dc.creatorNg, Veronicaspa
dc.creatorYeung, Vincentspa
dc.creatorYang, Mengluspa
dc.creatorCuchillo-Ibáñez, Inmaculadaspa
dc.creatorJüngert, Katharinaspa
dc.creatorSharma, Nikhilspa
dc.creatorMejía-Salgado, Germánspa
dc.creatorde la Torre Cifuentes, Ligia Alejandraspa
dc.creatorAgrawal, Rupeshspa
dc.creatorRojas-Carabali, Williamspa
dc.creatorCifuentes-González, Carlosspa
dc.creatorLiang, Lispa
dc.creatorDatta, Ananyaspa
dc.creatorChen, Xiangjunspa
dc.creatorHeunen, Maurice M.T.H.spa
dc.creatorLingor, Paulspa
dc.creatorKessal, Karimaspa
dc.creatorBrignole-Baudouin, Françoisespa
dc.creatorSharma, Shrutispa
dc.creatorBoychev, Nikolayspa
dc.creatorBo Chiang, Jeremy Chungspa
dc.creatorHuertas-Bello, Marcelaspa
dc.creatorTravé-Huarte, Sòniaspa
dc.creatorFernandes, Rosaspa
dc.creatorJente, Schmeetzspa
dc.creatorClémence, Bonnetspa
dc.creatorvan de Sande, Nienkespa
dc.creatorGijs, Marliesspa
dc.date.accessioned2025-07-21T16:34:18Z
dc.date.available2025-07-21T16:34:18Z
dc.date.created2025-05-01spa
dc.date.issued2025-05-01spa
dc.description.abstractTear fluid is an emerging source of disease biomarkers, drawing attention due to its quick, inexpensive, and non-invasive collection. The advancements in detection techniques enable the measurement of ultra-low biomarker levels from small sample volumes typical of tear fluid. The lack of standardized protocols for collection, processing, and analysis of tear fluid remains a significant challenge. To address this, we convened the Tear Research Network Review Taskforce in 2022 to review protocols from the past three decades, providing a comprehensive overview of the methodologies used in tear fluid biomarker research. A total of 1484 articles published from January 1974 to May 2024 from two electronic databases, Embase and Ovid MEDLINE, were reviewed. An exponential increase in the number of articles on tear fluid biomarkers was observed from 2015 onwards. The two most commonly reported collection methods were; glass capillaries (45.2%), and Schirmer's strips (25%), with glass capillary tube collection remaining the most frequent method until 2019, when Schirmer's strips became the leading method. Most articles analyzed tear fluid proteins (65%) and focused on a single analyte (32.3%). In recent years, an increase was observed in the type and number of examined analytes. The differences in the reported methodologies and protocols underscore the need for standardization and harmonization within the field of tear fluid biomarkers to minimize methodological differences and reduce variability in clinical outcomes. Consistent and detailed reporting is essential for improving the reproducibility and validity of tear fluid studies, in order to advance their potential clinical applications.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.preteyeres.2025.101338spa
dc.identifier.issn1350-9462spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46045
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.ispartofProgress in Retinal and Eye Research Volume 106, May 2025, 101338spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1350946225000114?via%3Dihubspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceProgress in Retinal and Eye Researchspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSistema sensorialeng
dc.subject.keywordTear fluideng
dc.subject.keywordTear fluid collectioneng
dc.subject.keywordBiomarkerseng
dc.subject.keywordTear fluid analysiseng
dc.subject.keywordSchirmer’s stripeng
dc.subject.keywordGlass capillarieseng
dc.subject.keywordTear fluid applicationseng
dc.titleA comprehensive scoping review of methodological approaches and clinical applications of tear fluid biomarkersspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de revisiónspa
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