Ítem
Acceso Abierto

Divergent short- and long-term effects of acute stress in object recognition memory are mediated by endogenous opioid system activation

Mostrar el registro sencillo de la publicación
dc.creatorNava Mesa, Mauricio Orlandospa
dc.creatorLamprea, Marisol R.spa
dc.creatorMúnera, Alejandrospa
dc.date.accessioned2020-05-25T23:57:21Z
dc.date.available2020-05-25T23:57:21Z
dc.date.created2013spa
dc.description.abstractAcute stress induces short-term object recognition memory impairment and elicits endogenous opioid system activation. The aim of this study was thus to evaluate whether opiate system activation mediates the acute stress-induced object recognition memory changes. Adult male Wistar rats were trained in an object recognition task designed to test both short- and long-term memory. Subjects were randomly assigned to receive an intraperitoneal injection of saline, 1. mg/kg naltrexone or 3. mg/kg naltrexone, four and a half hours before the sample trial. Five minutes after the injection, half the subjects were submitted to movement restraint during four hours while the other half remained in their home cages. Non-stressed subjects receiving saline (control) performed adequately during the short-term memory test, while stressed subjects receiving saline displayed impaired performance. Naltrexone prevented such deleterious effect, in spite of the fact that it had no intrinsic effect on short-term object recognition memory. Stressed subjects receiving saline and non-stressed subjects receiving naltrexone performed adequately during the long-term memory test; however, control subjects as well as stressed subjects receiving a high dose of naltrexone performed poorly. Control subjects' dissociated performance during both memory tests suggests that the short-term memory test induced a retroactive interference effect mediated through light opioid system activation; such effect was prevented either by low dose naltrexone administration or by strongly activating the opioid system through acute stress. Both short-term memory retrieval impairment and long-term memory improvement observed in stressed subjects may have been mediated through strong opioid system activation, since they were prevented by high dose naltrexone administration. Therefore, the activation of the opioid system plays a dual modulating role in object recognition memory. © 2013 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.nlm.2013.09.002
dc.identifier.issn10959564
dc.identifier.issn10747427
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22649
dc.language.isoengspa
dc.publisherAcademic Press Inc.spa
dc.relation.citationEndPage192
dc.relation.citationStartPage185
dc.relation.citationTitleNeurobiology of Learning and Memory
dc.relation.citationVolumeVol. 106
dc.relation.ispartofNeurobiology of Learning and Memory, ISSN:10959564, 10747427, Vol.106,(2013); pp. 185-192spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84884555706&doi=10.1016%2fj.nlm.2013.09.002&partnerID=40&md5=370e5f5d9b2d06397e6dcd12f5a82e25spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDynorphinspa
dc.subject.keywordphysicaleng
dc.subject.keywordKappa opiate receptorspa
dc.subject.keywordlong-termeng
dc.subject.keywordphysiologicaleng
dc.subject.keywordpsychologicaleng
dc.subject.keywordshort-termeng
dc.subject.keywordwistareng
dc.subject.keywordNaltrexonespa
dc.subject.keywordOpiatespa
dc.subject.keywordAcute stressspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordHabitatspa
dc.subject.keywordHumanspa
dc.subject.keywordHypothalamus hypophysis systemspa
dc.subject.keywordLong term memoryspa
dc.subject.keywordMalespa
dc.subject.keywordMemoryspa
dc.subject.keywordMemory disorderspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOpiod systemspa
dc.subject.keywordPattern recognitionspa
dc.subject.keywordPhysical activityspa
dc.subject.keywordRatspa
dc.subject.keywordRecognitionspa
dc.subject.keywordShort term memoryspa
dc.subject.keywordTask performancespa
dc.subject.keyword1mg/kg naltrexonespa
dc.subject.keyword1mg/kg naltrexone plus no-stressspa
dc.subject.keyword1mg/kg naltrexone plus stressspa
dc.subject.keyword3mg/kg naltrexonespa
dc.subject.keyword3mg/kg naltrexone plus no-stressspa
dc.subject.keyword3mg/kg naltrexone plus stressspa
dc.subject.keywordActhspa
dc.subject.keywordAcute stressspa
dc.subject.keywordAdrenocorticotropic hormonespa
dc.subject.keywordAnalysis of variancespa
dc.subject.keywordAnovaspa
dc.subject.keywordDispa
dc.subject.keywordDiscrimination indexspa
dc.subject.keywordEndogenous opioid systemspa
dc.subject.keywordFamiliar objectspa
dc.subject.keywordFospa
dc.subject.keywordN1nsspa
dc.subject.keywordN1sspa
dc.subject.keywordN3nsspa
dc.subject.keywordN3sspa
dc.subject.keywordNal 1spa
dc.subject.keywordNal 3spa
dc.subject.keywordNaltrexonespa
dc.subject.keywordNospa
dc.subject.keywordNovel objectspa
dc.subject.keywordObject recognition memoryspa
dc.subject.keywordObject recognition memoryspa
dc.subject.keywordObject recognition taskspa
dc.subject.keywordOrmspa
dc.subject.keywordOrtspa
dc.subject.keywordRetroactive interferencespa
dc.subject.keywordRetroactive interferencespa
dc.subject.keywordRispa
dc.subject.keywordSaline plus no-stressspa
dc.subject.keywordSaline plus stressspa
dc.subject.keywordSemspa
dc.subject.keywordSnsspa
dc.subject.keywordSsspa
dc.subject.keywordStandard error of the meanspa
dc.subject.keywordTfospa
dc.subject.keywordTime spent exploring the familiar objectspa
dc.subject.keywordTime spent exploring the novel objectspa
dc.subject.keywordTnospa
dc.subject.keywordVehspa
dc.subject.keywordVehiclespa
dc.subject.keywordAnimalsspa
dc.subject.keywordMalespa
dc.subject.keywordMemoryeng
dc.subject.keywordMemoryeng
dc.subject.keywordNaltrexonespa
dc.subject.keywordNarcotic antagonistsspa
dc.subject.keywordOpioid peptidesspa
dc.subject.keywordRatsspa
dc.subject.keywordRatseng
dc.subject.keywordRecognition (psychology)spa
dc.subject.keywordRestrainteng
dc.subject.keywordStresseng
dc.subject.keywordStresseng
dc.subject.keywordAcute stressspa
dc.subject.keywordEndogenous opioid systemspa
dc.subject.keywordNaltrexonespa
dc.subject.keywordObject recognition memoryspa
dc.subject.keywordRetroactive interferencespa
dc.titleDivergent short- and long-term effects of acute stress in object recognition memory are mediated by endogenous opioid system activationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1-s2-0-S1074742713001792-main.pdf
Tamaño:
943.62 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos