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The effect of Lucilia sericata- and Sarconesiopsis magellanica-derived larval therapy on Leishmania panamensis

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dc.creatorCruz-Saavedra, Lissaspa
dc.creatorDíaz-Roa, Andreaspa
dc.creatorGaona, María A.spa
dc.creatorCruz, Mónica L.spa
dc.creatorAyala, Marthaspa
dc.creatorCortés-Vecino, Jesús A.spa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorBello, Felio J.spa
dc.date.accessioned2020-05-26T00:04:09Z
dc.date.available2020-05-26T00:04:09Z
dc.date.created2016spa
dc.description.abstractThis study's main objective was to evaluate the action of larval therapy derived from Lucilia sericata and Sarconesiopsis magellanica (blowflies) regarding Leishmania panamensis using an in vivo model. Eighteen golden hamsters (Mesocricetus auratus) were used; they were divided into 6 groups. The first three groups consisted of 4 animals each; these, in turn, were internally distributed into subgroups consisting of 2 hamsters to be used separately in treatments derived from each blowfly species. Group 1 was used in treating leishmanial lesions with larval therapy (LT), whilst the other two groups were used for evaluating the used of larval excretions and secretions (ES) after the ulcers had formed (group 2) and before they appeared (group 3). The three remaining groups (4, 5 and 6), consisting of two animals, were used as controls in the experiments. Biopsies were taken for histopathological and molecular analysis before, during and after the treatments; biopsies and smears were taken for assessing parasite presence and bacterial co-infection. LT and larval ES proved effective in treating the ulcers caused by the parasite. There were no statistically significant differences between the blowfly species regarding the ulcer cicatrisation parameters. There were granulomas in samples taken from lesions at the end of the treatments. The antibacterial action of larval treatment regarding co-infection in lesions caused by the parasite was also verified. These results potentially validate effective LT treatment against cutaneous leishmaniasis aimed at using it with humans in the future. © 2016 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2016.09.020
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23663
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage289
dc.relation.citationStartPage280
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 164
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.164,(2016); pp. 280-289spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84989179388&doi=10.1016%2fj.actatropica.2016.09.020&partnerID=40&md5=9226cb2a5bf9da6828288f2a78aec7a1spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordExperimental studyspa
dc.subject.keywordcutaneouseng
dc.subject.keywordHistopathologyspa
dc.subject.keywordLarvaspa
dc.subject.keywordParasitespa
dc.subject.keywordRodentspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordAntibacterial activityspa
dc.subject.keywordArticlespa
dc.subject.keywordCalliphoridaespa
dc.subject.keywordClinical effectivenessspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease severityspa
dc.subject.keywordEscherichia coli infectionspa
dc.subject.keywordIn vivo studyspa
dc.subject.keywordKlebsiella pneumoniae infectionspa
dc.subject.keywordLeishmania panamensisspa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordMaggot therapyspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordSarconesiopsis magellanicaspa
dc.subject.keywordScar formationspa
dc.subject.keywordSkin leishmaniasisspa
dc.subject.keywordSkin ulcerspa
dc.subject.keywordSyrian hamsterspa
dc.subject.keywordAnimalspa
dc.subject.keywordBiological therapyspa
dc.subject.keywordDebridementspa
dc.subject.keywordDipteraspa
dc.subject.keywordHumanspa
dc.subject.keywordLarvaspa
dc.subject.keywordLeishmania guyanensisspa
dc.subject.keywordLeishmaniasiseng
dc.subject.keywordMesocricetusspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordParasitologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordSecretion (process)spa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordUlcerspa
dc.subject.keywordAnimaliaspa
dc.subject.keywordBacteria (microorganisms)spa
dc.subject.keywordCalliphoridaespa
dc.subject.keywordCricetinaespa
dc.subject.keywordLeishmania panamensisspa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordMesocricetus auratusspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordInsect proteinspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAnti-bacterial agentsspa
dc.subject.keywordBiological therapyspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordDebridementspa
dc.subject.keywordDipteraspa
dc.subject.keywordHumansspa
dc.subject.keywordInsect proteinsspa
dc.subject.keywordLarvaspa
dc.subject.keywordLeishmania guyanensisspa
dc.subject.keywordLeishmaniasiseng
dc.subject.keywordMesocricetusspa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordUlcerspa
dc.subject.keywordCo-infectionspa
dc.subject.keywordHamsterspa
dc.subject.keywordLarval excretions and secretionsspa
dc.subject.keywordLarval therapyspa
dc.subject.keywordLeishmania panamensisspa
dc.subject.keywordLucilia sericataspa
dc.subject.keywordSarconesiopsis magellanicaspa
dc.titleThe effect of Lucilia sericata- and Sarconesiopsis magellanica-derived larval therapy on Leishmania panamensisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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