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Treatment of acute methanol poisoning with fomepizole

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dc.creatorMelo Trujillo O.L.spa
dc.creatorAlonso Pérez D.spa
dc.creatorZabalza Cerdeiriña M.spa
dc.creatorNogué Xarau S.spa
dc.creatorGrau Junyent J.M.spa
dc.creatorMunné Mas P.spa
dc.date.accessioned2020-05-26T00:00:08Z
dc.date.available2020-05-26T00:00:08Z
dc.date.created2004spa
dc.description.abstractMethanol poisoning may cause metabolic acidosis, visual abnormalities and neurological dysfunction and may also result in severe sequelae or death. The treatment indicated is the administration of antidotes which inhibit the metabolization of the methanol by the alcohol dehydrogenase enzyme (ADH). Traditionally, ethyl alcohol has been used for this purpose, but recently, fomezipole, an inhibitor of alcohol dehydrogenase, has been introduced. We report on the first patient treated with this antidote in Spain. A 59-year-old man with a history of chronic alcoholism was admitted to the Emergency Department due to altered consciousness. Severe metabolic acidosis was detected and the patient admitted having consumed some 50 mL of rubbing alcohol. The serum methanol concentration was 0,24 g/l. Treatment was begun with sodium bicarbonate and fomepizole at a dose of 15 mg/kg, which was well-tolerated with no reappearance of acidosis. Reduced visual acuity and a small haemorrhage in the right optic papilla were observed, both of which were compatible with a toxic neuropathy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn16970748
dc.identifier.issn02127113
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23168
dc.language.isoengspa
dc.relation.citationEndPage43
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage41
dc.relation.citationTitleRevista de Toxicologia
dc.relation.citationVolumeVol. 21
dc.relation.ispartofRevista de Toxicologia, ISSN:16970748, 02127113, Vol.21, No.1 (2004); pp. 41-43spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-2542530091&partnerID=40&md5=e2e8e8e8801d9a734f6f9a8634b2e616spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword4 methylpyrazolespa
dc.subject.keywordAlcohol dehydrogenasespa
dc.subject.keywordBicarbonatespa
dc.subject.keywordMethanolspa
dc.subject.keywordAdultspa
dc.subject.keywordAlcohol blood levelspa
dc.subject.keywordAlcohol consumptionspa
dc.subject.keywordAlcoholismspa
dc.subject.keywordArticlespa
dc.subject.keywordCase reportspa
dc.subject.keywordClinical featurespa
dc.subject.keywordConsciousness disorderspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDrug tolerabilityspa
dc.subject.keywordFatalityspa
dc.subject.keywordHumanspa
dc.subject.keywordIntraocular hemorrhagespa
dc.subject.keywordMalespa
dc.subject.keywordMetabolic acidosisspa
dc.subject.keywordMetabolic inhibitionspa
dc.subject.keywordMethanol poisoningspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordNeuropathyspa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordVisual acuityspa
dc.subject.keywordVisual disorderspa
dc.subject.keyword4-methilpyrazolespa
dc.subject.keywordFomepizolespa
dc.subject.keywordMethanolspa
dc.titleTreatment of acute methanol poisoning with fomepizolespa
dc.title.TranslatedTitleTratamiento con fomepizol de una intoxicación aguda por metanolspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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