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Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity

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dc.creatorMancera-Páez, Oscarspa
dc.creatorRomán, Gustavo C.spa
dc.creatorPardo-Turriago, Rodrigospa
dc.creatorRodríguez Velandia, Yhojan Alexisspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-06-11T13:20:47Z
dc.date.available2020-06-11T13:20:47Z
dc.date.created2018spa
dc.description.abstractWe review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barré syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM+GBS) affecting a 24-year-old woman from Cúcuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed by serum reverse transcriptase-polymerase chain reaction (RT-PCR) and convalescent ZIKV IgG antibodies. With intensive care treatment, respiratory support, steroids, and intravenous immunoglobulin (IVIg), patient survived with residual flaccid paraparesis. She had preexisting immunity against Chikungunya virus (CHIKV) and Dengue virus (DENV) acquired before the arrival of ZIKV in Colombia. From reports in the Caribbean, Central and South America we review 19 cases of ZIKV-associated TM, encephalitis and ADEM occurring after a mean latent period of 10.5 days (range 1–96) post-infection. Although GBS and ADEM are usually considered post-infectious and associated with development of antibodies against peripheral nerve and CNS epitopes, we postulate that our case of ADEM+GBS is para-infectious, induced by acute ZIKV neurotropism boosted by active immunity against other arboviruses. Animal models of ZIKV demonstrated strong viral neurotropism enhanced by passive immunity with antibodies against arboviruses such as West Nile virus, CHIKV, or DENV. These considerations are relevant to prevent potential ZIKV vaccine-induced reactions involving central and peripheral nervous system. © 2018 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jns.2018.09.028
dc.identifier.issn0022510X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24576
dc.language.isoeng
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage53
dc.relation.citationStartPage47
dc.relation.citationTitleJournal of the Neurological Sciences
dc.relation.citationVolumeVol. 395
dc.relation.ispartofJournal of the Neurological Sciences, ISSN:0022510X, Vol.395, No. (2018); pp. 47-53spa
dc.relation.urihttps://www.jns-journal.com/action/showPdf?pii=S0022-510X%2818%2930390-3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulinspa
dc.subject.keywordMethylprednisolonespa
dc.subject.keywordAcute disseminated encephalomyelitisspa
dc.subject.keywordAdultspa
dc.subject.keywordAssisted ventilationspa
dc.subject.keywordCase reportspa
dc.subject.keywordClinical articlespa
dc.subject.keywordEncephalitisspa
dc.subject.keywordFemalespa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunityspa
dc.subject.keywordMuscle action potentialspa
dc.subject.keywordMyelitisspa
dc.subject.keywordNeurotropismspa
dc.subject.keywordNuclear magnetic resonance imagingspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReverse transcription polymerase chain reactionspa
dc.subject.keywordReviewspa
dc.subject.keywordYoung adultspa
dc.subject.keywordZika feverspa
dc.subject.keywordActive immunizationspa
dc.subject.keywordComplicationspa
dc.subject.keywordDiagnostic imagingspa
dc.subject.keywordEncephalitisspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMyelitisspa
dc.subject.keywordZika feverspa
dc.subject.keywordEncephalitisspa
dc.subject.keywordFemalespa
dc.subject.keywordGuillain-barre syndromespa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityspa
dc.subject.keywordactivespa
dc.subject.keywordMyelitisspa
dc.subject.keywordtransversespa
dc.subject.keywordYoung adultspa
dc.subject.keywordZika virus infectionspa
dc.subject.keywordAcute disseminated encephalomyelitisspa
dc.subject.keywordColombiaspa
dc.subject.keywordGuillain-barré syndromespa
dc.subject.keywordPost-infectious encephalitisspa
dc.subject.keywordTransverse myelitisspa
dc.subject.keywordZika virusspa
dc.titleConcurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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