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Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma auris

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dc.creatorRosenau, Frankspa
dc.creatorFiracative Ropero, Sandra Carolinaspa
dc.creatorStenger, Steffenspa
dc.creatorWolfgang Knollspa
dc.creatorKleber, Christophspa
dc.creatorStändker, Ludgerspa
dc.creatorRodriguez-Alfonso, Armandospa
dc.creatorPreising, Nicospa
dc.creatorMartell-Huguet, Ernesto M.spa
dc.creatorAlpízar-Pedraza, Danielspa
dc.creatorGruber, Danielspa
dc.creatorKissmann, Ann-Kathrinspa
dc.creatorWalter, Jan-Christophspa
dc.date.accessioned2025-07-21T16:52:28Z
dc.date.available2025-07-21T16:52:28Z
dc.date.created2025-03-01spa
dc.date.issued2025-03-01spa
dc.description.abstractBiofilms are the predominant lifeforms of microorganisms, contributing to over 80% of infections, including those caused by Candida species like C. albicans, C. parapsilosis and Candidozyma auris. These species form biofilms on medical devices, making infections challenging to treat, especially with the rise in drug-resistant strains. Candida infections, particularly hospital-acquired ones, are a significant health threat due to their resistance to antifungals and the risk of developing systemic infections (i.e., sepsis). We have previously shown that C14R reduces the viability of C. albicans and C. auris, but not of C. parapsilosis. Here, we show that C14R not only inhibits viability by pore formation, shown in a resazurin reduction assay, and in a C. parapsilosis and fluorescence-based permeabilization assay, but it also halts biofilm maturation and significantly reduces the biomass of preformed biofilms by over 70%. These findings suggest C14R could be an effective option for treating severe fungal infections, offering a potential new treatment approach for biofilm-related diseases. Further research is needed to fully understand its biofilm dispersal potential and to optimize its use for future applications as an antifungal in clinical settings.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.3390/biom15030322spa
dc.identifier.issn2218-273Xspa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46100
dc.language.isoengspa
dc.publisherMDPIspa
dc.relation.ispartofBiomolecules 2025, 15(3), 322spa
dc.relation.urihttps://www.mdpi.com/2218-273X/15/3/322spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceBiomoleculesspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBioquímicaeng
dc.subject.keywordNovel antifungalseng
dc.subject.keywordInfectious diseaseeng
dc.subject.keywordNext-generation antimycoticeng
dc.titleAntimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma aurisspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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