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Fatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventions

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dc.creatorPalacios-Espinosa, Ximenaspa
dc.creatorTalero-Gutierrez, Claudiaspa
dc.creatorGaviria-Carrillo, Marianaspa
dc.creatorGarcia-Moreno, Lunaspa
dc.creatorChicue-Cuervo, Paula Catalinaspa
dc.creatorDiaz-Quiroz Mateospa
dc.date.accessioned2025-07-21T16:43:22Z
dc.date.available2025-07-21T16:43:22Z
dc.date.created2025-02-13spa
dc.date.issued2025-02-13spa
dc.description.abstractIntroduction: Fatigue is a highly prevalent symptom in people with multiple sclerosis. It demands careful assessment and prompt intervention to improve their quality of life and overall burden of disease. This scoping review aims to provide a comprehensive synthesis and update of the existing evidence on the effectiveness of different pharmacological and nonpharmacological interventions for multiple sclerosis (MS)-related fatigue. Methods: To ensure the transparency and quality of the articles chosen for this scoping review, the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols extension for Scoping Reviews was used. Exclusively randomized controlled trials published between 2016 and 2023 were included. Results: Twenty-eight articles were analyzed. We found that pharmacological interventions are few and have included the use of Amantadine, Ondansetron, Methylphenidate, and Modafinil, with little effects on fatigue. Nonpharmacological interventions are diverse and include cognitive behavioral therapy, guided imagery, phototherapy, exercise, brain stimulation, and lavender administration with evidence of a statistically significant decrease in fatigue. Conclusions and Discussion: Current evidence on the effectiveness of pharmacological and nonpharmacological interventions is inconclusive. Lack of knowledge of the pathophysiology of fatigue limits its prevention, control, and management recommendations. A comprehensive and interdisciplinary approach is required to manage this symptom in patients with MS.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1177/20552173241312527spa
dc.identifier.issn2055-2173spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46070
dc.language.isoengspa
dc.publisherSage Journalsspa
dc.relation.ispartofSLEEP January–March 2025, 1–22spa
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/20552173241312527spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceSLEEPspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordFatigueeng
dc.subject.keywordMultiple sclerosiseng
dc.subject.keywordRestless legs syndromeeng
dc.subject.keywordInsomniaeng
dc.subject.keywordCircadian rhythmeng
dc.titleFatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventionsspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de revisiónspa
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