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Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design

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dc.creatorRodriguez L.E.spa
dc.creatorCurtidor H.spa
dc.creatorUrquiza M.spa
dc.creatorCifuentes G.spa
dc.creatorReyes C.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-26T00:04:04Z
dc.date.available2020-05-26T00:04:04Z
dc.date.created2008spa
dc.description.abstractA first step in the development of a logical and rational methodology for obtaining vaccines against the threatening effects of malaria has been a thorough analysis of the intimate molecular interactions of the molecules involved in P. falciparum's invasion of red blood cells (RBC) including secondary and 3D structure determination of some of them. Blocking the interactions could specifically be induced by activating the immune system with these molecules. Developing a completely effective vaccine against the parasite's blood stage must therefore involve a similar number of conserved high-activity bending peptides (HABPs) derived from some of the proteins that are directly involved in RBC invasion being blocked by the immune system. Data on the number of HABPs, their presence, processed and released fragments, network interactions, and merozoite-membrane-rafts shows the complexity of the processes involved in merozoite invasion of RBCs.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1021/cr068407v
dc.identifier.issn15206890
dc.identifier.issn00092665
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23653
dc.language.isoengspa
dc.publisherAmerican Chemical Societyspa
dc.relation.citationEndPage3705
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage3656
dc.relation.citationTitleChemical Reviews
dc.relation.citationVolumeVol. 108
dc.relation.ispartofChemical Reviews, ISSN:15206890, 00092665, Vol.108, No.9 (2008); pp. 3656-3705spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-53549133088&doi=10.1021%2fcr068407v&partnerID=40&md5=a79c96ffe9ebcb03b4b6134cea176c0espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCellsspa
dc.subject.keywordImmune systemspa
dc.subject.keywordMolecular interactionsspa
dc.subject.keywordMolecular structurespa
dc.subject.keywordMoleculesspa
dc.subject.keywordProteinsspa
dc.subject.keywordVaccinesspa
dc.subject.keyword3D Structurespa
dc.subject.keywordHigh activityspa
dc.subject.keywordNetwork interactionspa
dc.subject.keywordPspa
dc.subject.keywordFalciparumspa
dc.subject.keywordParasitespa
dc.subject.keywordRed blood cellspa
dc.subject.keywordSimilar numbersspa
dc.subject.keywordBloodspa
dc.titleIntimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine designspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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