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HLA-DRB1 the notorious gene in the mosaic of autoimmunity

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dc.creatorArango M.-T.spa
dc.creatorPerricone C.spa
dc.creatorKivity S.spa
dc.creatorCipriano E.spa
dc.creatorCeccarelli F.spa
dc.creatorValesini G.spa
dc.creatorShoenfeld Y.spa
dc.date.accessioned2020-05-26T00:11:06Z
dc.date.available2020-05-26T00:11:06Z
dc.date.created2017spa
dc.description.abstractThe major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12026-016-8817-7
dc.identifier.issn0257277X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24281
dc.language.isoengspa
dc.publisherHumana Press Inc.spa
dc.relation.citationEndPage98
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage82
dc.relation.citationTitleImmunologic Research
dc.relation.citationVolumeVol. 65
dc.relation.ispartofImmunologic Research, ISSN:0257277X, Vol.65, No.1 (2017); pp. 82-98spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978763593&doi=10.1007%2fs12026-016-8817-7&partnerID=40&md5=d95e7ed96b3c119df05a268d2abcee27spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHepatitis B surface antigenspa
dc.subject.keywordHepatitis B vaccinespa
dc.subject.keywordHLA DRB1 antigenspa
dc.subject.keywordInfluenza vaccinespa
dc.subject.keywordMeasles vaccinespa
dc.subject.keywordMumps vaccinespa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordHLA DRB1 antigenspa
dc.subject.keywordVaccinespa
dc.subject.keywordAnkylosing spondylitisspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCytomegalovirus infectionspa
dc.subject.keywordEpstein Barr virus infectionspa
dc.subject.keywordEthnicityspa
dc.subject.keywordGenespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGraves diseasespa
dc.subject.keywordGuillain Barre syndromespa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordHepatitis Cspa
dc.subject.keywordHLA DRB1 genespa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordInfectionspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor histocompatibility complexspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordMyositisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPsoriatic arthritisspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSpondylarthritisspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordVaccinationspa
dc.subject.keywordAnimalspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGeneticsspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordHLA-DRB1 Chainsspa
dc.subject.keywordHumansspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordVaccinesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordDRB1spa
dc.subject.keywordGenespa
dc.subject.keywordGeneticspa
dc.subject.keywordHLA systemspa
dc.subject.keywordInfectionsspa
dc.subject.keywordLocusspa
dc.subject.keywordVaccinesspa
dc.titleHLA-DRB1 the notorious gene in the mosaic of autoimmunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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