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Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?

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dc.creatorHeber, Siachoque M.spa
dc.creatorValero, Oscarspa
dc.creatorAntonio, Iglesias G.spa
dc.date.accessioned2020-05-25T23:59:36Z
dc.date.available2020-05-25T23:59:36Z
dc.date.created2013spa
dc.description.abstractSince the first studies in immunology, there has been a clear need to understand how, under normal conditions, the immune system tolerates its own antigens and attacks some foreign antigens that it perceives as potentially dangerous and how, in certain circumstances, the loss of tolerance triggers autoimmune diseases. It has been over half a century since Billingham, Brent and Medawar demonstrated, in an experimental model, the mechanisms involved in the development of immunological tolerance. Since then transplant immunologists have intensively investigated the mechanisms involved in maintaining tolerance, in the hope of avoiding the complications of non-specific immunosuppression, as well as the prevention of chronic rejection. An important characteristic was observed by Medawar, who argued that during transplantation an individual's immune system is tolerant to transplanted tissue, maintaining the response to other antigens. Recent studies have shown that loss of tolerance to transplantation is associated with a hyper-response to antigens of the transplanted tissue; a problem that has plagued clinical immunologists, who have focused their efforts on developing accurate measurement systems to enable them to measure how an individual could be tolerant to transplant. Attempts to induce tolerance in the individual are based on understanding the basic mechanisms of tolerance, in which there has been significant progress. This growth in knowledge has been in parallel with a better appreciation of the complexity of immune tolerance. In particular, progress has been made in understanding the essential role of tolerogenic dendritic cells (CDS) and the maintenance of tolerance by regulatory T cells. © 2013 Asociación Colombiana de Reumatología. Published by Elsevier España, S.L. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/S0121-8123(13)70138-5
dc.identifier.issn01218123
dc.identifier.issn20279000
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23073
dc.language.isoengspa
dc.publisherAsociacion Colombiana de Reumatologiaspa
dc.relation.citationEndPage249
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage237
dc.relation.citationTitleRevista Colombiana de Reumatologia
dc.relation.citationVolumeVol. 20
dc.relation.ispartofRevista Colombiana de Reumatologia, ISSN:01218123, 20279000, Vol.20, No.4 (2013); pp. 237-249spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85026339979&doi=10.1016%2fS0121-8123%2813%2970138-5&partnerID=40&md5=e9c53efa93789f6c43d9a12f754f999espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordChronic graft rejectionspa
dc.subject.keywordanergyeng
dc.subject.keywordHumanspa
dc.subject.keywordImmune systemspa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordImmunosuppressive treatmentspa
dc.subject.keywordMeasurement accuracyspa
dc.subject.keywordRegulatory t lymphocytespa
dc.subject.keywordReviewspa
dc.subject.keywordTissue transplantationspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordAutoreactivityeng
dc.subject.keywordDendritic cellsspa
dc.subject.keywordT regulatory cellsspa
dc.subject.keywordTolerancespa
dc.titleImmune tolerance, a walk through time: How does the immune system differentiate between self and foreign?spa
dc.title.TranslatedTitleTolerancia inmunológica, un recorrido en el tiempo: ¿Cómo discriminar entre lo propio y lo extraño?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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